PMID: 11897842Mar 19, 2002Paper

Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex

The Journal of Physiology
Nathaniel N UrbanGermán Barrionuevo

Abstract

We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC.

References

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S Goldman-RakicM Geffard
Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Dec 15, 1993·The Journal of Comparative Neurology·J B LevittJ S Lund
Aug 14, 1995·The Journal of Comparative Neurology·M F Kritzer, P S Goldman-Rakic
Dec 23, 1996·The Journal of Comparative Neurology·M L PucakD A Lewis
Nov 14, 1997·Journal of Neurophysiology·M WatanabeK Hikosaka
Feb 7, 1998·The Journal of Comparative Neurology·D S MelchitzkyD A Lewis
Jan 7, 1999·Journal of Computational Neuroscience·M Camperi, X J Wang
Dec 9, 2000·Journal of Neurophysiology·D A HenzeG Barrionuevo
Dec 29, 2000·Nature Neuroscience·D DurstewitzT J Sejnowski
Jan 1, 1995·Journal of Cognitive Neuroscience·T M Preuss

❮ Previous
Next ❯

Citations

Nov 7, 2006·Psychopharmacology·Christopher C LapishJeremy K Seamans
Nov 13, 2008·Cognitive Neurodynamics·Vaibhav A DiwadkarPéter Erdi
Jan 16, 2003·Physiology & Behavior·G González-BurgosG Barrionuevo
Dec 25, 2003·Neural Networks : the Official Journal of the International Neural Network Society·F Gregory Ashby, Michael B Casale
Feb 6, 2007·Nature Neuroscience·Susheel VijayraghavanAmy F T Arnsten
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Vardhan S DaniSacha B Nelson
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sarah Emerson LeeJohn R Hepler
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zdravko PetanjekIvica Kostovic
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Victor de Lafuente, Ranulfo Romo
Apr 13, 2012·Journal of Neurophysiology·A V ZaitsevD A Lewis
Mar 13, 2010·International Journal of Biological Sciences·Amy M Knab, J Timothy Lightfoot
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yun Wang, Patricia S Goldman-Rakic
Sep 5, 2008·Neural Plasticity·Douglas A Caruana, C Andrew Chapman
Sep 9, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Kara L AgsterBarry D Waterhouse
Apr 22, 2010·CNS Neuroscience & Therapeutics·Véronique M AndréMichael S Levine
Sep 24, 2004·Progress in Neurobiology·Jeremy K Seamans, Charles R Yang
Jun 16, 2015·Frontiers in Systems Neuroscience·Ioan OprisSam A Deadwyler
Aug 2, 2011·Current Biology : CB·Rosalyn J MoranRaymond J Dolan
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alireza SoltaniTirin Moore
Dec 23, 2009·Neuroscience and Biobehavioral Reviews·Dustin WahlstromMonica Luciana
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anissa Abi-Dargham, Holly Moore
Oct 8, 2004·Journal of Neurophysiology·Susanta BandyopadhyayJohn J Hablitz
Jul 30, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shao-Pii OnnAnthony A Grace
Feb 15, 2018·Frontiers in Neuroanatomy·Gabriele Radnikow, Dirk Feldmeyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.