PMID: 8960397Sep 1, 1996Paper

Selective reduction in domoic acid toxicity in vivo by a novel non-N-methyl-D-aspartate receptor antagonist

Canadian Journal of Physiology and Pharmacology
R Andrew TaskerJ Drejer

Abstract

Our objective was to characterize the neurotoxic actions of systemically administered domoic acid on different excitatory amino acid receptors, and to compare the receptor selectivity of domoate with the related compound kainic acid. Groups of mice were injected with various ligands selective for N-methyl-D-aspartate (NMDA) and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid-kainate (AMPA/kainate) receptors prior to injection of equitoxic doses of domoic acid or kainic acid. Domoic acid toxicity was not significantly altered by pretreatment with any NMDA receptor selective antagonists, with the exception of 3-(2-carboxypiperazine-4-yl)propyl-1 -phosphonic acid. Consistent with its characterization as an AMPA/kainate agonist, domoate toxicity was significantly antagonized by all non-NMDA receptor antagonists tested. Non-NMDA receptor antagonists that do not distinguish between high- and low-affinity [3H]kainic acid binding (i.e., quinoxalinediones) were equally effective at reducing domoic acid and kainic acid toxicity. However, the novel isatinoxime NS-102, which has been shown to interact selectively with low-affinity [3H]kainic acid binding sites, produced a selective dose-related antagonism of domoic acid toxicity ...Continue Reading

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Citations

Aug 5, 2000·European Journal of Pharmacology·B A QuintelaM Alfonso
Dec 20, 2000·Neurotoxicology and Teratology·T A DoucetteR A Tasker
Aug 30, 2000·Journal of Pharmacological and Toxicological Methods·N CrawfordD J de Vries
Aug 30, 2008·Marine Drugs·Olga M Pulido
Jun 12, 2003·Neurotoxicology and Teratology·Tracy A DoucetteCatherine L Ryan
Jun 10, 2009·Toxicon : Official Journal of the International Society on Toxinology·Kathi A Lefebvre, Alison Robertson
Nov 4, 2008·Toxicon : Official Journal of the International Society on Toxinology·Rex MundayLesley L Rhodes
Jul 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·P M SawantD S Kerr
Mar 15, 2006·Neurotoxicology and Teratology·Shenfeng Qiu, Margarita C Currás-Collazo
May 31, 2011·Epilepsy Research·P Perez-MendesL E Mello
Oct 21, 2015·Progress in Neurobiology·Amber L MarriottR Andrew Tasker
Jun 28, 2011·The American Journal of Pathology·Alexandra Vranyac-TramoundanasIvan A Sammut
May 1, 1999·Natural Toxins·D R Hampson, J L Manalo

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