Selective representation of task-relevant objects and locations in the monkey prefrontal cortex.

The European Journal of Neuroscience
Stefan EverlingJohn Duncan

Abstract

In the monkey prefrontal cortex (PFC), task context exerts a strong influence on neural activity. We examined different aspects of task context in a temporal search task. On each trial, the monkey (Macaca mulatta) watched a stream of pictures presented to left or right of fixation. The task was to hold fixation until seeing a particular target, and then to make an immediate saccade to it. Sometimes (unilateral task), the attended pictures appeared alone, with a cue at trial onset indicating whether they would be presented to left or right. Sometimes (bilateral task), the attended picture stream (cued side) was accompanied by an irrelevant stream on the opposite side. In two macaques, we recorded responses from a total of 161 cells in the lateral PFC. Many cells (75/161) showed visual responses. Object-selective responses were strongly shaped by task relevance - with stronger responses to targets than to nontargets, failure to discriminate one nontarget from another, and filtering out of information from an irrelevant stimulus stream. Location selectivity occurred rather independently of object selectivity, and independently in visual responses and delay periods between one stimulus and the next. On error trials, PFC activity fo...Continue Reading

References

Feb 1, 1989·Journal of Neurophysiology·S FunahashiP S Goldman-Rakic
Dec 1, 1988·Journal of Neuroscience Methods·C F CristR H Wurtz
May 1, 1966·Journal of Applied Physiology·A F Fuchs, D A Robinson
Aug 13, 1971·Science·J M Fuster, G E Alexander
Jan 1, 1995·Annual Review of Neuroscience·R Desimone, J Duncan
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D N Pandya, E H Yeterian
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G RainerE K Miller
Mar 4, 2000·Nature Neuroscience·J B HopfingerG R Mangun
Jul 19, 2000·Journal of Neurophysiology·W F AsaadE K Miller
Sep 9, 2000·Journal of Neurophysiology·R P HasegawaA Mikami
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Apr 3, 2001·Annual Review of Neuroscience·E K Miller, J D Cohen
Jun 22, 2001·Nature·J D WallisE K Miller
Oct 16, 2001·Journal of Neurophysiology·J LauwereynsO Hikosaka
Nov 21, 2001·Nature Reviews. Neuroscience·J Duncan
Jan 18, 2002·Nature·Natasha Sigala, Nikos K Logothetis
Jun 18, 2002·Nature Neuroscience·Stefan EverlingJohn Duncan
Sep 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David Gaffan
Oct 16, 2002·Nature Neuroscience·Daniel H O'ConnorSabine Kastner
May 9, 2003·Journal of Neurophysiology·Jonathan D Wallis, Earl K Miller
Dec 31, 2003·Nature Neuroscience·Alla IgnashchenkovaPeter Thier
Aug 13, 2004·The European Journal of Neuroscience·Yoshio SakuraiMasato Inoue
Feb 19, 2005·Science·Christian K MachensCarlos D Brody

❮ Previous
Next ❯

Citations

Jul 22, 2008·Experimental Brain Research·Stephen P WegenerStefan Everling
Oct 24, 2012·Behavioral Neuroscience·Tara L MooreMark B Moss
Feb 6, 2009·Cerebral Cortex·Makoto KusunokiJohn Duncan
Jan 27, 2010·Cerebral Cortex·Claire WardakGuy A Orban
Mar 24, 2009·Journal of Cognitive Neuroscience·Makoto KusunokiJohn Duncan
Nov 30, 2012·Journal of Cognitive Neuroscience·Joy J GengMichael J Minzenberg
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelsey L ClarkTirin Moore
Nov 22, 2013·ISRN Neurology·Jeffrey D Schall
Feb 18, 2010·Biological cybernetics·Martijn MeeterJan Theeuwes
Oct 27, 2010·Neuropsychologia·Luca CocchiMicah M Murray
Nov 4, 2015·Neuron·Narcisse P BichotRobert Desimone
Jul 21, 2009·The European Journal of Neuroscience·Gustavo Deco, Alexander Thiele
May 4, 2011·Annals of the New York Academy of Sciences·Emma C SarroDan H Sanes
Jun 8, 2011·Behavioural Brain Research·Jessica Sänger, Edmund Wascher
Aug 13, 2008·Vision Research·Diane M Beck, Sabine Kastner
Sep 19, 2016·NeuroImage·Valeria ParlatiniMichel Thiebaut de Schotten
Oct 22, 2008·NeuroImage·Yigal AgamRobert Sekuler
Feb 2, 2010·Journal of the Experimental Analysis of Behavior·Eunjeong LeeCyriel M A Pennartz
Feb 14, 2020·Attention, Perception & Psychophysics·Kiki ArkesteijnArtem V Belopolsky
Nov 24, 2015·Annual Review of Vision Science·Jeffrey D Schall
Jun 29, 2021·PLoS Computational Biology·Adarsh Chitradurga AchuthaDieter Vanderelst

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.