Selective responses of human gingival fibroblasts and bacteria on carbon fiber reinforced polyetheretherketone with multilevel nanostructured TiO2

Biomaterials
Xiao WangXinquan Jiang

Abstract

The long-term success of dental implants relies not only on stable osseointegration but also on the integration of implant surfaces with surrounding soft tissues. In our previous work, titanium plasma immersion ion implantation (PIII) technique was applied to modify the carbon-fiber-reinforced polyetheretherketone (CFRPEEK) surface, constructing a unique multilevel TiO2 nanostructure thus enhancing certain osteogenic properties. However, the interactions between the modified surface and soft-tissue cells are still not clear. Here, we fully investigate the biological behaviors of human gingival fibroblasts (HGFs) and oral pathogens on the structured surface, which determine the early peri-implant soft tissue integration. Scanning electron microscopy (SEM) shows the formation of nanopores with TiO2 nanoparticles embedded on both the sidewall and bottom. In vitro studies including cell adhesion, viability assay, wound healing assay, real-time PCR, western blot and enzyme-linked immunosorbent assay (ELISA) disclose improved adhesion, migration, proliferation, and collagen secretion ability of HGFs on the modified CFRPEEK. Moreover, the structured surface exhibits sustainable antibacterial properties towards Streptococcus mutans, Fu...Continue Reading

References

Apr 1, 1991·Clinical Oral Implants Research·T BerglundhP Thomsen
Nov 1, 1982·The Journal of Cell Biology·R O Hynes, K M Yamada
Oct 16, 1999·Journal of Clinical Periodontology·I S MoonJ Lindhe
Jul 28, 2004·Biomaterials·Annette DienerJoachim Rychly
Oct 29, 2005·Journal of Periodontology·Thomas W OatesBjorn Steffensen
Nov 9, 2005·The Journal of Prosthetic Dentistry·Heidi L Myshin, Jonathan P Wiens
Oct 3, 2006·Water Research·Laura K AdamsPedro J J Alvarez
Apr 4, 2008·The Journal of Prosthetic Dentistry·Peter Schupbach, Roland Glauser
Aug 10, 2007·Biomaterials·Steven M Kurtz, John N Devine
Mar 12, 2008·Implant Dentistry·Evan D Tetelman, Charles A Babbush
May 22, 2008·Clinical Oral Implants Research·Maria WelanderTord Berglundh
Aug 16, 2008·Journal of Materials Science. Materials in Medicine·S C Scholes, A Unsworth
Oct 27, 2009·Developmental Biology·Tania Rozario, Douglas W DeSimone
Sep 13, 2011·The Journal of Oral Implantology·Andreas Schwitalla, Wolf-Dieter Müller
Apr 3, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ichiro NakaharaNobuhiko Sugano
Apr 20, 2012·Advanced Drug Delivery Reviews·Noreen J Hickok, Irving M Shapiro
Nov 9, 2012·Journal of Clinical Periodontology·Victoria R KearnsNicolas Martin
Jun 15, 2013·Clinical Oral Implants Research·Denis CecchinatoJan Lindhe
Jun 21, 2013·Journal of Biomedical Materials Research. Part a·Chang YaoMatthew Hedrick
Jul 10, 2013·Acta Odontologica Scandinavica·Shaza BishtiWael Att
Mar 14, 2014·International Journal of Nanomedicine·Xiangning LiuLei Zhou
Aug 8, 2014·Brazilian Oral Research·Eduardo Aloisio Fleck NeumannFabiana Mantovani Gomes França
Nov 5, 2014·Clinical Oral Implants Research·Joshua ChouMakoto Otsuka
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Anxiu XuShicheng Wei
Feb 24, 2015·ACS Applied Materials & Interfaces·Jianliang HeZisheng Tang
Mar 18, 2015·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Chuan Silvia LiMohit Bhandari
Apr 16, 2015·Clinical Implant Dentistry and Related Research·Yulan WangRichard J Miron

❮ Previous
Next ❯

Citations

Oct 27, 2016·Journal of Biomedical Materials Research. Part a·Yu ZhuHongchang Lai
May 13, 2017·Journal of Biomedical Materials Research. Part a·M N BiaoB C Yang
Nov 24, 2018·Advanced Healthcare Materials·Carlos Mas-MorunoMatthew J Dalby
Aug 29, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaolin WuHui Huang
Dec 28, 2018·Clinical Implant Dentistry and Related Research·Sunil Mishra, Ramesh Chowdhary
Feb 28, 2019·Clinical Implant Dentistry and Related Research·Vincent MilleretAnn Wennerberg
Mar 13, 2019·Clinical Implant Dentistry and Related Research·Cristiano SusinPeter Schüpbach
Jan 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erhui JiangZhengjun Shang
Nov 16, 2019·Clinical Implant Dentistry and Related Research·Wen ZhouLei Cheng
Jun 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ningjia SunXinquan Jiang
Aug 28, 2020·Journal of Biomaterials Science. Polymer Edition·Yue YuYi Deng
Oct 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Xiaocheng ZhouZhengjun Shang
May 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jie WangXinquan Jiang
Jan 30, 2021·Frontiers in Bioengineering and Biotechnology·Xinming GuYanmin Zhou
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Karan GulatiSašo Ivanovski
Feb 23, 2020·The Journal of Prosthetic Dentistry·Maryam GheisarifarMorteza Rasoulianboroujeni
May 1, 2021·Frontiers in Bioengineering and Biotechnology·Jianxu WeiHongchang Lai
Mar 11, 2019·ACS Biomaterials Science & Engineering·Liping OuyangXuanyong Liu
Dec 9, 2019·ACS Biomaterials Science & Engineering·Lanyu WangXuanyong Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.