Selective retrograde labeling indicating the transmitter of neuronal pathways

The Journal of Comparative Neurology
P Streit

Abstract

A number of tritiated transmitter related compounds-amino acids and biogenic amines-were injected into the rat caudoputamen or substantia nigra in order to test (1) for the occurence of autoradiographic perikaryal labeling, (2) for a selectivity of perikaryal labeling relating certain compounds to certain pathways, and (3) for the relation of perikaryal labeling to known transmitter specificitites of the systems involved. Perikaryal labeling was observed after injection of some but not all of the substances used and was best explained by retrograde labeling in pathways projecting to the injection sites. Six hours after injection of high concentrations of tritiated transmitter into the terminal area, perikaryal labeling was observed: (A) in substantial nigra compacta (A9), A10 (rostral) and A8 (all heavy), and in n. raphe dorsalis (light) after [3H]-dopamine and [3H]-norepinephrine injection into caudoputamen; (B) same pattern as in A, but heavy in n. raphe dorsalis after [3H]-serotonin injection into caudoputamen; perikaryal labeling absent in cortex and thalamus after injection of substances mentioned in A and B; (C) only in substantia nigra compacta (minimally) after [3H]-GABA injection into caudoputamen; (D) in cerebral cort...Continue Reading

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