PMID: 2510399Jan 1, 1989Paper

Selective segmental hepatic necrosis produced by the Shwartzman mechanism in rabbits

Virchows Archiv. A, Pathological Anatomy and Histopathology
Y OhnoW Mori

Abstract

In this study, a new experimental model for hepatic necrosis is presented using rabbits, and E. coli endotoxin as the Shwartzman reagent. A segment of the liver was chosen as a target site for the univisceral Shwartzman reaction. Endotoxin-Lipiodol emulsion was used as a preparative injection via the portal venous branch into the target segment by direct puncture. Provocation was made by an intravenous injection of endotoxin 24 h later. A marked and sharply demarcated necrotic area was produced selectively in the target segment; specific changes were not seen in other lobes of the liver or other parts of the body. This model, strongly enhanced by using Lipiodol, seems to be a subtype of the univisceral Shwartzman reaction of the liver.

References

May 31, 1979·Virchows Archiv. A, Pathological Anatomy and Histology·W MoriA Kato
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·H AoyamaW Mori
Aug 1, 1986·Seminars in Liver Disease·W MoriH Irie
Dec 1, 1972·American Journal of Obstetrics and Gynecology·G Müller-Berghaus, B Schmidt-Ehry
Jun 5, 1954·Journal of the American Medical Association·A THAL, E BRACKNEY
Mar 1, 1958·The Journal of Experimental Medicine·S S SHAPIRO, D G McKAY
Feb 1, 1965·The Journal of Experimental Medicine·J LEVIN, L E CLUFF

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.