Selective sensitization of C-fiber nociceptors by hydrogen sulfide

Journal of Pharmacological Sciences
Yuka AokiAtsufumi Kawabata

Abstract

We examined the effects of intraplantar (i.pl.) administration of NaHS, an H2S donor, known to cause T-type Ca(2+) channel (T-channel)-dependent mechanical hyperalgesia, on responsiveness to electric stimulation with 5, 250 and 2000 Hz sine waves (SW) that selectively excites C, Aδ and Aβ fibers, respectively. NaHS, given i.pl., caused behavioral hypersensitivity to SW stimulation at 5 Hz, but not 250 or 2000 Hz, in rats. NaHS also enhanced phosphorylation of spinal ERK following 5 Hz SW stimulation. Three distinct T-channel blockers abolished the NaHS-induced behavioral hypersensitivity to 5 Hz SW stimulation. Thus, H2S selectively sensitizes C-fiber nociceptors via T-channels.

References

Mar 10, 2007·Pain·Atsufumi KawabataHiroyuki Nishikawa
Feb 11, 2011·British Journal of Pharmacology·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Aug 2, 2013·Journal of Pharmacological Sciences·Fumiko Sekiguchi, Atsufumi Kawabata
Feb 5, 2014·Nitric Oxide : Biology and Chemistry·Hideo Kimura

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.