Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: the MESA-right ventricle study.

PloS One
Corey E VentetuoloSteven M Kawut

Abstract

Serotonin and the serotonin transporter have been implicated in the development of pulmonary hypertension (PH). Selective serotonin reuptake inhibitors (SSRIs) may have a role in PH treatment, but the effects of SSRI use on right ventricular (RV) structure and function are unknown. We hypothesized that SSRI use would be associated with RV morphology in a large cohort without cardiovascular disease (N = 4114). SSRI use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were assessed via cardiac magnetic resonance imaging. The cross-sectional relationship between SSRI use and each RV measure was assessed using multivariable linear regression; analyses for RV mass and end-diastolic volume (RVEDV) were stratified by sex. After adjustment for multiple covariates including depression and left ventricular measures, SSRI use was associated with larger RV stroke volume (RVSV) (2.75 mL, 95% confidence interval [CI] 0.48-5.02 mL, p = 0.02). Among men only, SSRI use was associated with greater RV mass (1.08 g, 95% CI 0.19-1.97 g, p = 0.02) and larger RVEDV (7.71 mL, 95% 3.02-12.40 mL, p = 0.001). SSRI use may have been associated with larger RVEDV among women and larger...Continue Reading

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Citations

May 27, 2014·The International Journal of Cardiovascular Imaging·Ezgi KalaycıoğluSükrü Celik
Apr 23, 2013·Cell Biochemistry and Biophysics·Luigi Michele Pavone, Russell A Norris
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Sep 13, 2018·Current Vascular Pharmacology·Evangelia MaretiDimitrios G Goulis

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Clinical Trials Mentioned

NCT00190333

Software Mentioned

STATA
QMASS
MESA
Windows

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