Selective serotonin reuptake inhibitors increase sympathetic activity under heavy alcohol exposure in rat models

Life Sciences
Tsung-Ming HuRu-Ping Lee

Abstract

Self-medication with alcohol while being treated with antidepressants is a common problem in patients with depression. Both alcohol consumption and antidepressant administration can induce changes in the cardiac autonomic responses as indicated by heart rate variability (HRV). In this study, we examined cardiac autonomic responses induced by acute heavy alcohol exposure after SSRIs (selective serotonin reuptake inhibitors) medications. Rats were randomly divided into 3 groups, the alcohol administrated (Alc group), paroxetine administrated (SSRI group), and the SSRI+Alc group. Serum samples were collected to measure blood alcohol concentration (BAC). Physiological and cardiac autonomic responses including mean arterial pressure (MAP), heart rate (HR), and HRV were also compared among groups. The SSRI group exhibited higher values of HRV and HF (high frequency) than did the Alc and SSRI+Alc groups after alcohol administration. In contrast to the Alc group, the SSRI+Alc group had significantly lower MAP than Alc group, and higher HR, standard deviation of NN-intervals (SDNN), SDNN to MRR ratio (CVNN), square root of the mean squared differences of the successive NN-intervals (RMSSD) and HF values after alcohol administration. Our...Continue Reading

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Citations

Feb 9, 2019·Alcoholism, Clinical and Experimental Research·Vatsalya VatsalyaVijay A Ramchandani
Aug 28, 2020·Cardiovascular Toxicology·Danielle Cristiane Correa De PaulaAndrea Grabe-Guimarães

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