PMID: 15379025Sep 24, 2004Paper

Selective source blocking for Gamma Knife radiosurgery of trigeminal neuralgia based on analytical dose modelling

Physics in Medicine and Biology
Kaile Li, Lijun Ma

Abstract

We have developed an automatic critical region shielding (ACRS) algorithm for Gamma Knife radiosurgery of trigeminal neuralgia. The algorithm selectively blocks 201 Gamma Knife sources to minimize the dose to the brainstem while irradiating the root entry area of the trigeminal nerve with 70-90 Gy. An independent dose model was developed to implement the algorithm. The accuracy of the dose model was tested and validated via comparison with the Leksell GammaPlan (LGP) calculations. Agreements of 3% or 3 mm in isodose distributions were found for both single-shot and multiple-shot treatment plans. After the optimized blocking patterns are obtained via the independent dose model, they are imported into the LGP for final dose calculations and treatment planning analyses. We found that the use of a moderate number of source plugs (30-50 plugs) significantly lowered (approximately 40%) the dose to the brainstem for trigeminal neuralgia treatments. Considering the small effort involved in using these plugs, we recommend source blocking for all trigeminal neuralgia treatments with Gamma Knife radiosurgery.

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Citations

Jul 29, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Katsuhiro Toda
May 10, 2006·International Journal of Radiation Oncology, Biology, Physics·Nicolas MassagerMarc Levivier
Jul 7, 2016·Neurology India·Ajay Niranjan, L Dade Lunsford
Nov 15, 2012·Journal of Applied Clinical Medical Physics·Gopishankar NatanasabapathiA K Mahapatra

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