PMID: 8588323May 1, 1995Paper

Selective spread and reduced virus release leads to canine distemper virus persistence in the nervous system

Veterinary Microbiology
A ZurbriggenM Vandevelde

Abstract

In primary dog brain cell cultures (DBCC) the attenuated canine distemper virus (CDV) is cytolytic, whereas virulent CDV is not. Thus, the question why cytolysis does or does not occur appears to be intimately associated with the mechanism of persistence. Persistence is most likely related to the way these viruses replicate. In the present study we used morphological and immunocytochemical approaches to compare several aspects of virus replication between a cytolytic and a virulent CDV strain using DBCC to study both strains. Quantitative measurements did not detect a difference in the rate of virus protein synthesis at the level of the single cell, between the two types of infection. Electron microscopical results and virus titration experiments showed marked differences in virus spread and virus release. Immunocytochemical studies showed differences in the distribution of the nucleocapsid and matrix proteins between the two infections. Budding and cytolysis are strongly limited in the virulent A75/17-CDV infection as compared to attenuated viruses. This is probably due to structural changes in the virus proteins leading to modifications of virus assembly. Thus the present study supports a mechanism of CDV persistence through ...Continue Reading

Citations

Jan 1, 1995·Acta Neuropathologica·C F MüllerA Zurbriggen
Jun 30, 1997·Veterinary Microbiology·M StettlerA Zurbriggen
Jan 5, 2000·Microbes and Infection·K IwatsukiC Kai
Nov 30, 2012·Advances in Virology·Otávio Valério CarvalhoAbelardo Silva Júnior
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H HelfrichS H Ralston
Nov 6, 2010·Ecological Applications : a Publication of the Ecological Society of America·Emily S AlmbergDouglas W Smith
Jan 13, 2005·Acta Neuropathologica·Marc Vandevelde, Andreas Zurbriggen
Nov 21, 2008·Veterinary Immunology and Immunopathology·A BeinekeW Baumgärtner
Jun 21, 2006·Virology Journal·Li-Yen ChangSazaly AbuBakar
Apr 26, 2016·Viruses·Philippe PlattetHector C Aguilar
Dec 12, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T L CaddP Liljeström
Jul 30, 2003·Animal Health Research Reviews·Christian GriotAndreas Zurbriggen

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