PMID: 38408Apr 30, 1979

Selective stimulation of central alpha-autoreceptors following treatment with alpha-methyldopa and FLA 136

Naunyn-Schmiedeberg's Archives of Pharmacology
N E ANDEN

Abstract

1. The accumulation of normetanephrine in the rat brain induced by the monoamine oxidase inhibitor nialamide was inhibited following alpha-methyldopa and 4-amino-3-(2,6-dichlorobenzylidenehydrazino)-1,2,4-triazole (FLA 136). It was not changed following alpha-methylmetatyrosine despite a greater disappearance of noradrenaline than after alpha-methyldopa. The alpha-adrenoreceptor blocking agent yohimbine increased the nialamide-induced accumulation of normetanephrine and completely antagonized the actions of alpha-methyldopa and FLA 136, indicating that the effects of the two drugs are due to stimulation of alpha-adrenoreceptors. 2. The flexor reflex activity of spinalized rats was not influenced by alpha-methyldopa and alpha-methylmetatyrosine at the doses used in the biochemical experiments, as previously found for FLA 136, indicating no stimulation of classical, postsynaptic, central alpha-adrenoreceptors. 3. The biochemical effects of alpha-methyldopa and FLA 136 might be caused by stimulation of alpha-autoreceptors on the cell bodies and the nerve terminals of noradrenaline neurons. A similar mechanism might be involved in the hypotension reported by other investigators following these drugs.

Citations

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Jul 18, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·N E ANDEN, M Grabowska
Jan 1, 1978·Reviews of Physiology, Biochemistry and Pharmacology· Kobinger
Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·P B TimmermansP A van Zwieten
Oct 1, 1975·International Journal of Radiation Oncology, Biology, Physics·H P SchultzH S Kaplan
Sep 8, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A Heise, G Kroneberg
May 1, 1970·Life Sciences·N E ANDENT Svensson
Feb 1, 1973·British Journal of Pharmacology·L Finch, G Haeusler
Oct 1, 1968·European Journal of Pharmacology·N E ANDENT MAGNUSSON
Dec 15, 1958·Acta Physiologica Scandinavica·A BERTLERE ROSENGREN
Jan 1, 1962·Acta Physiologica Scandinavica·A CARLSSON, M LINDQVIST

Related Concepts

Yohimbin Spiegel
Normetanephrine
Nialamide
Brain
Sembrina
Triazoles
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Agonists
Drug Interactions
Reflex Action

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