PMID: 6969775Dec 1, 1980Paper

Selective suppression of retroviral gp70-anti-gp70 immune complex formation by prostaglandin E1 in murine systemic lupus erythematosus

The Journal of Experimental Medicine
S IzuiF J Dixon

Abstract

The effect of pharmacologic quantities of prostaglandin E1 (PGE) was investigated in three strains of mice (NZB X NZW, MRL/1, and BXSB) that spontaneously develop lupus-like glomerulonephritis. PGE-treatment prolonged survival and retarded the glomerular deposition of immune complex (IC) and the development of glomerulonephritis in NZB X NZW and MRL/1 mice, but did not similarly protect BXSB mice. Changes in the responsive strains correlated well with reduced amounts of circulating gp70 complexed with anti-gp70 antibodies compared with untreated controls, although total concentrations of gp70 (free and complexed) detectable in sera were similar in both groups of mice. The results strongly suggest that: (a) PGE selectively suppressed the immune response to retroviral gp70, (b) PGe had little effect on the quantity or quality of anti-DNA antibodies but did reduce the deposition of anti-DNA containing IC in the kidneys, and (c) gp70 IC appear to play an important role in the pathogenesis of glomerulonephritis in murine systemic lupus erythematosus.

References

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Citations

Oct 1, 1983·Journal of Clinical Immunology·J S Goodwin, J Ceuppens
Mar 1, 1982·Prostaglandins·K R McLeishD L Sustarsic
Jan 1, 1987·Prostaglandins·J S Goodwin, G A Clay
Jan 1, 1986·International Journal of Immunopharmacology·J S Goodwin, G A Clay
Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·K KatoS Murota
Aug 1, 1981·The Journal of Experimental Medicine·S IzuiF J Dixon
Feb 1, 1982·The Journal of Experimental Medicine·I HaraF J Dixon
Oct 1, 1982·The Journal of Experimental Medicine·C RordorfM B Pepys
Sep 1, 1984·Acta Pathologica Japonica·H IshikuraT Itoh
Jan 1, 1994·International Reviews of Immunology·A Shirai, D M Klinman
Jan 1, 1981·Immunological Reviews·A N Theofilopoulos, F J Dixon
Jun 1, 1982·Clinical Immunology and Immunopathology·V E Kelley, E Wing
Nov 1, 1981·Clinical Immunology and Immunopathology·V E KelleyF J Dixon
Aug 1, 1981·Clinical Immunology and Immunopathology·A Winkelstein, V E Kelley
Jul 1, 1982·Arthritis and Rheumatism·R B Zurier
Mar 1, 1995·Clinical and Experimental Immunology·Y UtsunomiyaO Sakai
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucie BaudinoShozo Izui
Jul 1, 1982·Arthritis and Rheumatism·A N Theofilopoulos
Jan 1, 1984·Journal of Immunopharmacology·R P CarlsonA J Lewis
Sep 1, 1992·The Journal of International Medical Research·E N Wardle
Jan 1, 1988·Life Sciences·P Dore-DuffyR B Zurier
Jan 1, 1986·Journal of Cellular Biochemistry·J D Young, Z A Cohn

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