Selective survival of calretinin- and vasoactive-intestinal-peptide-containing nerve elements in human chagasic submucosa and mucosa

Cell and Tissue Research
S JabariAxel Brehmer

Abstract

Chronic Chagas' disease is frequently characterized by massive myenteric neuron loss resulting in megacolon with severely and irreversibly disturbed motility. Here, we focused on two submucosal neuron populations, immunoreactive for calretinin (CALR) or somatostatin (SOM), and their respective mucosal nerve fibres in chagasic megacolon. Surgically removed megacolonic segments of seven chagasic patients were compared with seven age- and region-matched non-chagasic control segments. Evaluation included immunohistochemical triple-staining of cryosections for CALR, SOM and peripherin or for CALR and vasoactive intestinal peptide (VIP) and of submucosal whole-mounts for CALR, SOM and the pan-neuronal marker anti-HuC/D. Submucosal neuron counts in chagasic tissue revealed neuron numbers reduced to 51.2 % of control values. In cryosections, nerve fibre area measurements revealed 8.6 % nerve fibre per mucosal area in control segments, but this value decreased to 1.5 % in megacolonic segments. In both evaluations, a disproportionate decrease of SOM-reactive nerve elements was observed. The proportions of SOM-positive neurons related to the total neuron number declined to 2 % (control 10 %) and the proportion of SOM-reactive mucosal nerv...Continue Reading

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Citations

Feb 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Charles H KnowlesRoberto De Giorgio
Nov 10, 2013·Histochemistry and Cell Biology·Nicholas BeuscherAxel Brehmer
Jul 26, 2014·Histochemistry and Cell Biology·Samir JabariAlexandre B M da Silveira
Mar 13, 2014·Parasite Immunology·W O DutraK J Gollob
May 20, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Y OdaE J A Araújo
May 1, 2021·Journal of Immunology Research·José Rodrigues do Carmo NetoMarcos Vinícius da Silva

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