Selective Targeting of Different Bromodomains by Small Molecules

Cancer Cell
Jun Qi, Yang Shi

Abstract

Two papers, published in Science and Nature, report inhibitiors selectively targeting distinct bromodomains of BET proteins. These advanced chemical tools facilitate functional understanding of epigenetic regulators in normal and disease states and enable development of new medicine potentially with lower toxicity.

References

Sep 28, 2010·Nature·Panagis FilippakopoulosJames E Bradner
Nov 12, 2010·Nature·Edwige NicodemeAlexander Tarakhovsky
Dec 18, 2013·Nature Biotechnology·Lars AndersRichard A Young
May 12, 2015·Nature Biotechnology·Junwei ShiChristopher R Vakoc
Oct 25, 2016·Nature Chemical Biology·Minoru TanakaJames E Bradner
Oct 25, 2016·Nature Chemical Biology·Michael J WaringYi Yao

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Citations

May 13, 2021·Nature Reviews. Gastroenterology & Hepatology·Sheng CaoVijay H Shah

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