Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29

Nutrition and Cancer
S R MuskI T Johnson

Abstract

It has previously been observed that allyl isothiocyanate, a compound naturally present in the diet, is more cytotoxic toward the human colorectal adenocarcinoma cell line HT29 in its control transformed state than after exposure to sodium butyrate or to dimethylformamide, which slow growth and induce differentiation (detransformation). In the present study, a range of other dietary compounds were assayed for such selective toxicity. These compounds were chosen as constituents of foodstuffs that have been identified from epidemiologic studies as being potentially antitumorigenic and also as having anticarcinogenic activity in experimental models. Benzyl and phenethyl isothiocyanate, benzyl thiocyanate, and quercetin showed decreased toxicity towards HT29 after detransformation of the cells by one or both treatments, whereas no change was observed in the sensitivity to diallyl sulfide or diallyl disulfide. It is proposed that the presence of such selectively toxic compounds in the diet may inhibit the development of tumors by interfering with the growth of preneoplastic lesions while having little effect on normal cells. The cumulative effects of these inhibitions may contribute to the chemopreventive properties of the parent fo...Continue Reading

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Citations

May 15, 2001·International Journal of Cancer. Journal International Du Cancer·M A LeaC desBordes
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I T Johnson
Jun 19, 2002·The Proceedings of the Nutrition Society·I T Johnson
Dec 20, 2011·Mutation Research·Carmela FimognariPatrizia Hrelia
Feb 28, 1997·Chemico-biological Interactions·D T VerhoevenG van Poppel
Jun 25, 2008·The British Journal of Nutrition·Roberto PieriniIan T Johnson
Dec 8, 2016·Biomarkers in Medicine·Mattia BellanPier Paolo Sainaghi

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