Selective uptake of boronated low-density lipoprotein in melanoma xenografts achieved by diet supplementation

British Journal of Cancer
Y SetiawanB J Allen

Abstract

The lipid core of human plasma low-density lipoprotein (LDL) was extracted using hexane and the LDL reconstituted with the addition of n-octyl-carborane. Biodistribution studies of the boronated LDL were performed in BALB/c mice bearing subcutaneous Harding-Passey melanoma xenografts. When diet supplementation with coconut oil and cholesterol for 21 days and regular dosing with hydrocortisone for 7 days before the studies was used to down-regulate the liver LDL receptors and the adrenal receptors, respectively, the tumour-blood boron concentration ratio of 5:1 was achieved.

Citations

Nov 22, 2005·International Journal of Radiation Biology·Erika Bohl KullbergLars Gedda
Jun 23, 2006·Physics in Medicine and Biology·Barry J Allen
May 17, 2003·Journal of Neuro-oncology·Jörgen CarlssonLars Gedda
Feb 19, 2002·Chemical Reviews·Albert H. SolowayJ. Gerald Wilson

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