PMID: 11911498Mar 26, 2002Paper

Selective vulnerability in adult and ageing mammalian neurons

Autonomic Neuroscience : Basic & Clinical
T Cowen

Abstract

Data are presented in support of the idea of antagonistic pleiotropy that features which are adaptive during early life may become maladaptive during the ageing process, when selective pressure is reduced. A model of selective vulnerability to age-related neurodegeneration involving neighbouring subpopulations of vulnerable and protected sympathetic neurons is presented. The two groups of neurons are morphologically and physiologically distinct, indicating advantageous adaptation to particular functions. Neurotrophin signalling is investigated in these different groups of neurons, revealing significant differences between them: neurotrophic factor expression in their target tissues is markedly different, same as their neurotrophin uptake characteristics. Preliminary evidence is presented that the mechanism linking neurotrophin signalling and age-related neurodegeneration may involve the capacity of neurons to buffer free radical generation, hence reducing the effects of attrition by free radical damage.

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Citations

Feb 28, 2003·Neuroscience·M AperghisG Goldspink
Nov 26, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Vladimir ZivkovićMiljana Pavlović
Feb 6, 2013·World Journal of Gastroenterology : WJG·Kathy J LePard, Joseph Cellini
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lauren C LietsLeo M Chalupa
Oct 14, 2004·Microscopy Research and Technique·María Luisa Del MoralMaría Angeles Peinado
May 24, 2008·Neurobiology of Aging·Uros KovacicFajko F Bajrović
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P R Wade, T Cowen
Nov 19, 2003·The European Journal of Neuroscience·Oliver von Bohlen und HalbachKlaus Unsicker
Apr 17, 2008·The European Journal of Neuroscience·Raya Al-ShawiTimothy Cowen
Dec 13, 2005·Journal of Neurochemistry·Armando P SignoreJun Chen
Dec 23, 2014·Autonomic Neuroscience : Basic & Clinical·M Mónica Brauer, Peter G Smith
Oct 27, 2009·Hearing Research·Jianxin Bao, Kevin K Ohlemiller
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paul R Wade
Mar 28, 2009·Annals of Plastic Surgery·Uros KovacicFajko F Bajrović

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