Selectively bred rodents as models of depression and anxiety

Current Topics in Behavioral Neurosciences
Gregers WegenerInga D Neumann

Abstract

Stress related diseases such as depression and anxiety have a high degree of co morbidity, and represent one of the greatest therapeutic challenges for the twenty-first century. The present chapter will summarize existing rodent models for research in psychiatry, mimicking depression- and anxiety-related diseases. In particular we will highlight the use of selective breeding of rodents for extremes in stress-related behavior. We will summarize major behavioral, neuroendocrine and neuronal parameters, and pharmacological interventions, assessed in great detail in two rat model systems: The Flinders Sensitive and Flinders Resistant Line rats (FSL/FRL model), and rats selectively bred for high (HAB) or low (LAB) anxiety related behavior (HAB/LAB model). Selectively bred rodents also provide an excellent tool in order to study gene and environment interactions. Although it is generally accepted that genes and environmental factors determine the etiology of mental disorders, precise information is limited: How rigid is the genetic disposition? How do genetic, prenatal and postnatal influences interact to shape adult disease? Does the genetic predisposition determine the vulnerability to prenatal and postnatal or adult stressors? In ...Continue Reading

Citations

Feb 13, 2016·Frontiers in Cellular Neuroscience·Barbara Di BenedettoRainer Rupprecht
Apr 4, 2017·Journal of Molecular and Cellular Cardiology·John P HeadrickNicolas J C Stapelberg
Dec 5, 2018·Acta Neuropsychiatrica·Francesco AngelucciAleksander A Mathé
Apr 24, 2015·Acta Neuropsychiatrica·Thea Pinholt LillethorupAnne Marlene Landau
Apr 5, 2014·British Journal of Pharmacology·N Kokras, C Dalla
Jan 16, 2013·Pharmacological Reviews·David H Overstreet, Gregers Wegener
Dec 16, 2011·The Journal of Pharmacology and Experimental Therapeutics·A MørkT Bryan Stensbøl
Sep 15, 2019·Translational Psychiatry·Anna K SchmidtnerInga D Neumann
Dec 19, 2014·The International Journal of Neuropsychopharmacology·Alessandra MalleiMaurizio Popoli
Mar 15, 2020·Journal of Neuroscience Research·Victoria A MalikBarbara Di Benedetto
May 4, 2020·Neuroscience and Biobehavioral Reviews·Marjorie C Gondré-LewisKenneth Blum
Feb 8, 2021·Behavioural Brain Research·Randhall B CarteriLuis Valmor Portela

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