Selectively expanding subsets of T cells in mice by injection of interleukin-2/antibody complexes: implications for transplantation tolerance

Transplantation Proceedings
Onur BoymanJonathan Sprent

Abstract

The biological activity of interleukin (IL)-2 and other cytokines in vivo can be augmented by binding to certain anti-cytokine monoclonal antibodies (mAb). Here, we review evidence on how IL-2/anti-IL-2 mAb complexes can be used to cause selective stimulation and expansion of certain T-cell subsets. With some anti-IL-2 mAbs, injection of IL-2/mAb complexes leads to expansion of CD8 T effector cells but not CD4 T regulatory cells (Tregs); these complexes exert less adverse side effects than soluble IL-2 and display powerful antitumor activity. Other IL-2/mAb complexes have minimal effects on CD8 T cells but cause marked expansion of Tregs. Preconditioning mice with these complexes leads to permanent acceptance of MHC-disparate pancreatic islets in the absence of immunosuppression.

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Aug 28, 2010·Advances in Experimental Medicine and Biology·Onur BoymanJonathan Sprent

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Citations

Mar 27, 2013·Molecular Diagnosis & Therapy·Diana P EnglishAlessandro D Santin
Aug 21, 2013·International Reviews of Immunology·Jens Vent-SchmidtMegan K Levings
Jan 15, 2014·Expert Review of Clinical Immunology·Denise Skrombolas, John G Frelinger
Mar 11, 2015·Scientific Reports·Sophie TeegeFriedrich Koch-Nolte
May 24, 2016·Nature Immunology·Rebecca B DelconteNicholas D Huntington
Jul 18, 2016·Experimental Hematology·Kaitlin A ReadKenneth J Oestreich
Sep 22, 2016·Nature Communications·Reza GhasemiAlexander Sasha Krupnick
Nov 7, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tamara Veiga-PargaBarry T Rouse
Jun 2, 2020·Journal of Leukocyte Biology·Kamila Bendickova, Jan Fric
Nov 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryna E BurrellJonathan S Bromberg
Jul 22, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie T KimJohn T Harty

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