Selectively-Packaged Proteins in Breast Cancer Extracellular Vesicles Involved in Metastasis.

International Journal of Molecular Sciences
Penelope V DallaMatthew P Padula

Abstract

Cancer-derived extracellular vesicles are known to play a role in the progression of the disease. In this rapidly-growing field, there are many reports of phenotypic changes in cells following exposure to cancer-derived extracellular vesicles. This study examines the protein contents of vesicles derived from three well-known breast cancer cell lines, MCF-7, MDA-MB-231 and T47D, using peptide-centric LC-MS/MS and cytokine multiplex immunoassay analysis to understand the molecular basis of these changes. Through these techniques a large number of proteins within these vesicles were identified. A large proportion of these proteins are known to be important in cancer formation and progression and associated with cancer signaling, angiogenesis, metastasis and invasion and immune regulation. This highlights the importance of extracellular vesicles (EVs) in cancer communications and shows some of the mechanisms the vesicles use to assist in cancer progression.

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Citations

Jul 31, 2021·Cancer Management and Research·Yongqin DengDong Ye

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Methods Mentioned

BETA
protein assay
sandwich immunoassay
peptide assay
deamination

Software Mentioned

PEAKS Studio
Excel
DanteR
PEAKS
GraphPad Prism
Cytoscape
MS Excel
String

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