Abstract
1 The potencies of fifteen beta-adrenoceptor agonists of widely differing chemical structures were compared with that of (-)-isoprenaline on bronchial muscle, soleus muscle, blood pressure and heart rate in the anaesthetized cat. The beta-adrenoceptor antagonist potencies of propranolol and practolol were determined against (-)-isoprenaline in the same model. 2 (-)-Isoprenaline was the most potent agonist and its action was essentially unselective. Thus, on all four parameters the minimal effective dose was 0.003-0.01 mug/kg and maximal or near maximal responses were produced by 0.3-1 mug/kg. Trimetoquinol was also an essentially unselective agonist. 3 For thirteen of the remaining fourteen agonists, potency was similar on bronchial muscle, soleus muscle and blood pressure but significantly lower on heart rate. 4 The remaining agonist - AH 7616 (4-hydroxy-alpha1-[[(1-methyl-3,3-diphenyl-propyl)amino]-methyl]-m-xylene-alpha1, alpha3-diol, acetate) - was also significantly less potent on heart rate than on the other parameters; in addition, it was clearly less potent on soleus muscle and blood pressure than on bronchial muscle when 5-hydroxytryptamine (5-HT) was used to induce bronchospasm. However, when acetylcholine was used in...Continue Reading
References
Feb 1, 1975·British Journal of Clinical Pharmacology·G E Marlin, P Turner
Jan 1, 1975·The Journal of Pharmacy and Pharmacology·E J Cornish, R C Miller
Feb 1, 1975·British Journal of Pharmacology·M J DalyG P Levy
Jun 1, 1971·European Journal of Pharmacology·J R BoissierP Viars
Nov 1, 1972·British Journal of Pharmacology·M C GweeI W Rodger
Mar 1, 1973·Cardiovascular Research·E M WilliamsB N Singh
Nov 1, 1973·European Journal of Pharmacology·I W Rodger
May 1, 1973·British Medical Bulletin·D H Jenkinson
Jan 1, 1974·Clinical and Experimental Pharmacology & Physiology·T DaveyC Raper
Jan 1, 1970·British Journal of Pharmacology·W C Bowman, M W Nott
Jan 1, 1970·The Journal of Pharmacy and Pharmacology·J B FarmerR J Marshall
Sep 15, 1969·Experientia·J BergmanK Wetterlin
Mar 20, 1971·British Medical Journal·B J Freedman
Mar 20, 1971·British Medical Journal·J S LeggeK N Palmer
Feb 1, 1972·The Journal of Pharmacy and Pharmacology·G H Apperley, M J Daly
Oct 1, 1972·British Journal of Pharmacology·G M Drew, G P Levy
Nov 1, 1974·British Journal of Pharmacology·S R O'Donnell, J C Wanstall
Aug 1, 1972·British Journal of Pharmacology·W C Bowman, I W Rodger
Nov 1, 1971·British Journal of Pharmacology·M J DalyG P Levy
Apr 1, 1970·The Journal of Physiology·C D Marsden, J C Meadows
Jan 1, 1969·British Journal of Pharmacology·V A CullumG P Levy
May 6, 1967·Nature·A M LandsT G Brown
Dec 1, 1956·British Journal of Pharmacology and Chemotherapy·R P STEPHENSON
Nov 10, 1958·The Journal of Physiology·W C BOWMAN, E ZAIMIS
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Feb 1, 1960·The Journal of Physiology·A J BULLERR M ECCLES
Jun 1, 1948·The American Journal of Physiology·R P AHLQUIST
Jun 1, 1974·British Journal of Clinical Pharmacology·J M Watson, A Richens
Citations
Dec 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A A Al-Jeboory, R J Marshall
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Dec 1, 1977·European Journal of Pharmacology·D F ColellaJ R Wardell
Feb 1, 1978·European Journal of Pharmacology·S R O'Donnell, J C Wanstall
Jan 1, 1979·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·A F GreenI L Natoff
Jun 18, 2002·European Journal of Pharmacology·Bertil Waldeck
Apr 29, 1989·Lancet·J CraneR Beasley
Jan 1, 1981·Clinical and Experimental Pharmacology & Physiology·E HolmbergB Waldeck
Oct 1, 1991·Australian and New Zealand Journal of Medicine·R BeasleyC Burgess
Jun 1, 1977·British Journal of Pharmacology·H DowdC Raper
Jan 1, 1978·British Journal of Pharmacology·R S Gupta, V V Kelkar
Jan 1, 1995·Pharmacology & Toxicology·B Waldeck
Nov 23, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T Soić-VranićM Nikolić
Jul 10, 2007·The Veterinary Clinics of North America. Small Animal Practice·Lauren A Trepanier
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N PearceR Beasley
Sep 1, 1984·Clinical and Experimental Pharmacology & Physiology·Z Merican, P Morat
Jun 1, 1986·Clinical and Experimental Pharmacology & Physiology·Z MericanB A Khalid
Dec 1, 1992·Clinical and Experimental Pharmacology & Physiology·Z MericanB A Khalid
Apr 1, 1979·Acta Pharmacologica Et Toxicologica·O A OlssonB Waldeck
Mar 1, 1977·The Journal of Pharmacy and Pharmacology·K A BarkerI E Hughes
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Mar 1, 1986·Acta Pharmacologica Et Toxicologica·B WaldeckE Widmark
Oct 1, 1982·Acta Pharmacologica Et Toxicologica·P AnderssonB Waldeck
May 1, 1978·The Journal of Pharmacy and Pharmacology·S YamashitaY Yabuuchi
Mar 1, 1978·The Journal of Pharmacy and Pharmacology·B HarperF H Noormohamed
Oct 1, 1977·The Journal of Pharmacy and Pharmacology·P Lumley, K J Broadley
Feb 1, 1986·British Journal of Pharmacology·H E ConnorM J Perren
Oct 17, 1983·The American Journal of Medicine·W H FrishmanM P Poland