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Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors
British Journal of Pharmacology
May 1, 1977
J C DoxeyJ Michael Walker
PMID: 18248
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Abstract
1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors....read more
Mentioned in this Paper
Vas Deferens Structure
Synapses
Smooth Muscle
Z-Max
Isoglaucon
Norepinephrine
Norepinephrine, (+, -)-Isomer
Structure of Anococcygeal Nerve
Metazoa
Metabolic Inhibition
Paper Details
References
- References8
- Citations205
Presynaptic regulation of catecholamine release
Biochemical PharmacologyJuly 1, 1974Sara Langer
Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart
Naunyn-Schmiedeberg's Archives of PharmacologyJanuary 1, 1972Klaus StarkeComparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction
Naunyn-Schmiedeberg's Archives of PharmacologyJanuary 1, 1974Klaus StarkeR Merker
Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine
European Journal of PharmacologyDecember 1, 1975Klaus StarkeTakahiko Endo
Evidence against adrenergic motor transmission in the guinea-pig vas deferens
The Journal of PhysiologyJuly 1, 1971N P Ambache, Muhammad Abu Zar
Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine
ExperientiaMay 15, 1964Hans ThoenenW E Haefely
Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity
NatureApril 3, 1975Klaus StarkeH D Taube
Cardiovascular effects of prazosin in normotensive and genetically hypertensive rats
Clinical and Experimental Pharmacology & PhysiologyJanuary 1, 1975A Jeffrey WoodFiona Simpson
1
- References8
- Citations205
Novel alpha2-adrenoreceptors primarily responsible for inducing human platelet aggregation
NatureFebruary 22, 1979Jeffrey A Grant, M C Scrutton
The pharmacology of labetalol, an alpha- and beta-adrenoceptor blocking agent
General PharmacologyJanuary 1, 1978A G Blakeley, Roger James Summers
Potentiation of startle response by d- and l-amphetamine: the possible involvement of pre- and postsynaptic alpha-adrenoreceptors and other transmitter systems in the modulation of a tactile startle response
PsychopharmacologyJune 28, 1979Sheila L Handley, Kelan L H ThomasR 28935 and prazosin: effects on central and peripheral alpha-adrenoreceptor activity and on blood pressure
Naunyn-Schmiedeberg's Archives of PharmacologyMay 1, 1978N E AndénG G TrolinTolmesoxide, a drug that lowers blood pressure by a direct relaxant effect on vascular smooth muscle
British Journal of PharmacologyMay 1, 1978J C Doxey
Selectivities of some agonists acting at alpha 1- and alpha 2-adrenoreceptors in the rat vas deferens
Journal of Autonomic PharmacologyMarch 1, 1986J A Leedham, Jocelyn N PennefatherThe cardiovascular effects of MPV 295 [4(5)-2-(2,6-dimethylphenyl)ethylimidazole], a new antihypertensive agent with alpha 2-adrenoceptor agonistic properties
Naunyn-Schmiedeberg's Archives of PharmacologyMay 1, 1983Heikki J RuskoahoNiyanta Karki
Structure--activity relationships among novel phenoxybenzamine-related beta-chloroethylamines
Bioorganic & Medicinal ChemistryMay 1, 2002Dario Giardinà Carlo Melchiorre
Voltammetric and spectrophotometric techniques for the determination of the antihypertensive drug Prazosin in urine and formulations
Journal of Pharmaceutical and Biomedical AnalysisDecember 1, 1999Adela ArranzJ F ValentinPre- and postsynaptic alpha-adrenoceptor blocking activity of raubasine in the rat vas deferens
British Journal of PharmacologyDecember 1, 1981P DemichelJ Roquebert
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Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors
Abstract
1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors....read more
Mentioned in this Paper
Vas Deferens Structure
Synapses
Smooth Muscle
Z-Max
Isoglaucon
Related Papers
Paper Details
References
- References8
- Citations205
Presynaptic regulation of catecholamine release
Biochemical PharmacologyJuly 1, 1974Sara LangerAlpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart
Naunyn-Schmiedeberg's Archives of PharmacologyJanuary 1, 1972Klaus StarkeComparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction
Naunyn-Schmiedeberg's Archives of PharmacologyJanuary 1, 1974Klaus StarkeR MerkerPreferential blockade of presynaptic alpha-adrenoceptors by yohimbine
European Journal of PharmacologyDecember 1, 1975Klaus StarkeTakahiko EndoEvidence against adrenergic motor transmission in the guinea-pig vas deferens
The Journal of PhysiologyJuly 1, 1971N P Ambache, Muhammad Abu ZarDual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine
ExperientiaMay 15, 1964Hans ThoenenW E HaefelyPre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity
NatureApril 3, 1975Klaus StarkeH D TaubeCardiovascular effects of prazosin in normotensive and genetically hypertensive rats
Clinical and Experimental Pharmacology & PhysiologyJanuary 1, 1975A Jeffrey WoodFiona Simpson
1
- References8
- Citations205
Novel alpha2-adrenoreceptors primarily responsible for inducing human platelet aggregation
NatureFebruary 22, 1979Jeffrey A Grant, M C ScruttonThe pharmacology of labetalol, an alpha- and beta-adrenoceptor blocking agent
General PharmacologyJanuary 1, 1978A G Blakeley, Roger James SummersPotentiation of startle response by d- and l-amphetamine: the possible involvement of pre- and postsynaptic alpha-adrenoreceptors and other transmitter systems in the modulation of a tactile startle response
PsychopharmacologyJune 28, 1979Sheila L Handley, Kelan L H ThomasR 28935 and prazosin: effects on central and peripheral alpha-adrenoreceptor activity and on blood pressure
Naunyn-Schmiedeberg's Archives of PharmacologyMay 1, 1978N E AndénG G TrolinTolmesoxide, a drug that lowers blood pressure by a direct relaxant effect on vascular smooth muscle
British Journal of PharmacologyMay 1, 1978J C DoxeySelectivities of some agonists acting at alpha 1- and alpha 2-adrenoreceptors in the rat vas deferens
Journal of Autonomic PharmacologyMarch 1, 1986J A Leedham, Jocelyn N PennefatherThe cardiovascular effects of MPV 295 [4(5)-2-(2,6-dimethylphenyl)ethylimidazole], a new antihypertensive agent with alpha 2-adrenoceptor agonistic properties
Naunyn-Schmiedeberg's Archives of PharmacologyMay 1, 1983Heikki J RuskoahoNiyanta KarkiStructure--activity relationships among novel phenoxybenzamine-related beta-chloroethylamines
Bioorganic & Medicinal ChemistryMay 1, 2002Dario Giardinà Carlo MelchiorreVoltammetric and spectrophotometric techniques for the determination of the antihypertensive drug Prazosin in urine and formulations
Journal of Pharmaceutical and Biomedical AnalysisDecember 1, 1999Adela ArranzJ F ValentinPre- and postsynaptic alpha-adrenoceptor blocking activity of raubasine in the rat vas deferens
British Journal of PharmacologyDecember 1, 1981P DemichelJ Roquebert
12345...
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