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Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors

British Journal of Pharmacology

May 1, 1977

J C DoxeyJ M Walker

Abstract

1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors....read more

Mentioned in this Paper

Yohimbin Spiegel
Z-Max
Structure of Anococcygeal Nerve
Presynaptic Terminals
Phenoxybenzamine Hydrochloride
Antagonist Muscle Action
Contraction (Finding)
Smooth Muscle
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists
Paper Details
References
  • References8
  • Citations222
12345...

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Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors

British Journal of Pharmacology

May 1, 1977

J C DoxeyJ M Walker

PMID: 18248

DOI: 10.1111/j.1476-5381.1977.tb16752.x

Abstract

1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors....read more

Mentioned in this Paper

Yohimbin Spiegel
Z-Max
Structure of Anococcygeal Nerve
Presynaptic Terminals
Phenoxybenzamine Hydrochloride
Antagonist Muscle Action
Contraction (Finding)
Smooth Muscle
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Antagonists

Similar Papers Found In These Feeds

Synaptic Junctions

Synaptic or neuronal junctions are the site of transmission of electrical nerve impulses between neurons or between neurons and effector cells. Discover the latest research on synaptic junctions here.

Inotropic Agents & Heart Disease

Inotropic agents alter the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction. Inotropic agents are used in hospitalized patients with acute decompensated heart failure, with reduced left ventricular ejection fraction and with signs of end-organ dysfunction in the setting of a low cardiac output, or with severe systolic heart failure awaiting heart transplant to maintain hemodynamic stability or as a bridge to decision. Discover the latest research on inotrpic agents and heart diseases here.

Related Papers

European Journal of Pharmacology

Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine

European Journal of PharmacologyDecember 1, 1975
K StarkeT Endo
Paper Details
References
  • References8
  • Citations222
12345...
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