Abstract
Sensitizing chemicals can induce various types of allergic disease, including contact dermatitis and occupational asthma. In the present study we have examined the nature of the immune response induced in Brown Norway (BN) rats by oxazolone (OX), a potent contact allergen, and by trimellitic anhydride (TMA), a chemical known to cause sensitization of the respiratory tract and occupational asthma. BN rats were exposed topically to either OX or TMA at doses selected to achieve similar levels of proliferative activity by draining LNC. Both chemicals stimulated hapten-specific IgG antibody responses, but only TMA induced specific IgE antibody, an increase in total serum IgE and active sensitization of mast cells. Draining LNC from OX-treated rats expressed elevated IFN-gamma mRNA, whereas those from TMA-treated rats expressed elevated IL-5 mRNA compared to controls. Furthermore, Con A-activated draining LNC from rats exposed to TMA, but not OX, released significantly increased concentrations of IL-4. In conclusion, different chemical allergens can induce in the BN rat divergent patterns of IgE response and cytokine expression.
Citations
Jun 27, 2006·Journal of Occupational Medicine and Toxicology·Dingena L ValstarPaul A J Henricks
Feb 19, 2014·Toxicology·Ian KimberDarrell R Boverhof
Jan 29, 2002·International Immunopharmacology·Xing Dong ZhangDaniel M Lewis
Apr 17, 1998·Toxicology Letters·C A RyanF Gerberick
Nov 13, 2015·Contact Dermatitis·Helen SingletonRebecca J Dearman
Nov 21, 2007·Toxicology and Applied Pharmacology·Darrell R BoverhofMichael R Woolhiser
Jul 5, 2005·Toxicology and Applied Pharmacology·Dingena L ValstarPaul A J Henricks
Oct 17, 1998·Toxicology and Applied Pharmacology·J H ArtsN Bloksma
Jan 25, 2002·Journal of Applied Toxicology : JAT·E V WarbrickI Kimber
Jul 26, 2017·Human & Experimental Toxicology·Y HuangB Li
Jan 16, 2016·Anatomy & Cell Biology·Ok Hee Chai, Chang Ho Song
Jun 23, 2006·Luminescence : the Journal of Biological and Chemical Luminescence·Takashi Kumae, Hatsuko Arakawa
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Ian Kimber, Rebecca J Dearman
Mar 3, 2012·Experimental & Applied Acarology·M A KhanM A Birkett
Oct 30, 2008·Journal of Immunotoxicology·Jean F Regal
Aug 10, 2018·Toxicology Research·Ian KimberDavid A Basketter