Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson's Disease

Frontiers in Behavioral Neuroscience
Satoka KasaiHaruhiro Higashida

Abstract

Parkinson's disease (PD), a neurodegenerative disorder, is accompanied by various non-motor symptoms including depression and anxiety, which may precede the onset of motor symptoms. Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and is widely used in the treatment of PD and major depression. However, there are few reports about the effects of selegiline on non-motor symptoms in PD. The aim of this study was to explore the antidepressant and anxiolytic effects of selegiline, using CD157/BST1 knockout (CD157 KO) mouse, a PD-related genetic model displaying depression and anxiety, compared with other antiparkinsonian drugs and an antidepressant, and was to investigate the effects of selegiline on biochemical parameters in emotion-related brain regions. A single administration of selegiline (1-10 mg/kg) dose-dependently reduced immobility time in the forced swimming test (FST) in CD157 KO mice, but not C57BL/6N wild-type (WT) mice. At 10 mg/kg, but not 3 mg/kg, selegiline significantly increased climbing time in CD157 KO mice. A single administration of the antiparkinsonian drugs pramipexole (a dopamine (DA) D2/D3 receptor agonist) or rasagiline (another MAO-B inhibitor), and repeated injections of a noradrene...Continue Reading

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Citations

Nov 7, 2019·Journal of Clinical Psychopharmacology·Rémi MoirandClément Dondé
Dec 29, 2019·Cells·Haruhiro HigashidaOlga Lopatina
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuan DuFenghua Fu
Nov 22, 2017·Parkinson's Disease·Jéssica Lopes FontouraMarcelo Machado Ferro
Dec 12, 2020·Frontiers in Immunology·Olga L LopatinaAlla B Salmina

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Methods Mentioned

BETA
ELISA
blood collection

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SPSS
maze
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