Selegiline and lymphocyte superoxide dismutase activities in Parkinson's disease

Annals of Neurology
J KushleikaP D Swanson

Abstract

Superoxide dismutases (SODs) are metalloenzymes that detoxify superoxide radicals, and occur in cytosolic (Cu,Zn-SOD) and mitochondrial (Mn-SOD) forms in multiple tissues, including brain. A neuroprotective effect against oxide stressor exposures may be provided by SOD, although excessive enzyme activity can produce cell injury by formation of hydroxyl radical from hydrogen peroxide. We measured Cu,Zn-SOD and Mn-SOD activities in peripheral lymphocytes of 43 newly diagnosed idiopathic Parkinson's disease (PD) cases and 62 age- and sex-matched controls free of neurodegenerative disorders. Significant excesses of both SOD forms were found among PD cases compared with controls; however, the excesses were found exclusively among PD patients treated with the monoamine oxidase inhibitor selegiline (L-deprenyl). Enzyme-linked immunosorbent assays (ELISAs) confirmed that the activity excesses were due to increased protein rather than more highly reactive enzymes in lymphocytes of PD cases. Our findings clearly indicate the importance of selegiline on measured Cu,Zn-SOD and Mn-SOD activity in peripheral lymphocytes. Characterizing a possible therapeutic value of SOD will require longitudinal assessments of SOD in relation to PD progress...Continue Reading

References

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Citations

Jun 17, 2005·Journal of Neural Transmission·K TakahataA Akaike
Sep 1, 1999·Free Radical Biology & Medicine·E MartignoniG Nappi
Jul 2, 2008·Parkinsonism & Related Disorders·P FoleyP Riederer
Apr 1, 1997·Acta Neurologica Scandinavica·V V MyllyläE H Heinonen
Jan 25, 2013·International Journal of Molecular Sciences·Noemi Cardenas-RodriguezElvia Coballase-Urrutia
Apr 27, 2002·Annals of the New York Academy of Sciences·Kenichi KitaniMaria-Cristina Carrillo
Jan 4, 2019·Journal of Molecular Neuroscience : MN·Joanna A RuszkiewiczMichael Aschner

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