PMID: 8614567Nov 17, 1995Paper

Selegiline protects dopaminergic neurons in culture from toxic factor(s) present in the cerebrospinal fluid of patients with Parkinson's disease

Neuroscience Letters
R HaoR F Pfeiffer

Abstract

The cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) contains substance(s) that inhibit the growth and functions of dopaminergic neurons. Further, selegiline, a monoamine oxidase B (MAO) inhibitor (0.125-0.250 microM) enhanced the number of tyrosine hydroxylase (TH)-positive neurons, augmented the high affinity uptake of dopamine (DA), and averted the neurotoxic effects of CSF of PD patients on rat mesencephalic neurons in culture. The neuroprotective effects of selegiline may be related either to its ability to inhibit MAO B, preventing the generation of free radicals, or to neuronal rescue property due to unknown mechanisms.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A ProchiantzJ Glowinski
Oct 14, 1991·Neuroscience Letters·W G TattonN A Seniuk
Jan 1, 1991·European Neurology·A MangoniS Smirne
Apr 12, 1989·European Journal of Pharmacology·H L WienerH Sershen
Sep 29, 1989·Biochemical and Biophysical Research Communications·Y MizunoY Kagawa
Jun 3, 1989·Lancet·A H SchapiraC D Marsden
Aug 18, 1987·Neuroscience Letters·L Friedman, C Mytilineou
Jun 4, 1985·Neuroscience Letters·C MytilineouR E Heikkila
Jul 1, 1968·Biochemical Pharmacology·J P Johnston
Apr 30, 1984·Biochemical and Biophysical Research Communications·K ChibaN Castagnoli
Jan 21, 1993·The New England Journal of Medicine·UNKNOWN Parkinson Study Group

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Citations

Apr 1, 1997·Neurochemistry International·M EbadiN K Lassi
Aug 5, 2005·Biological & Pharmaceutical Bulletin·Kenji AbeKyoji Taguchi
Nov 21, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yaichiro Kotake
Mar 26, 2002·Brain : a Journal of Neurology·Pamela J Shaw
Feb 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Clement C ZaiJames L Kennedy

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