PMID: 2105506Feb 1, 1990Paper

Selenium and immune cell functions. II. Effect on lymphocyte-mediated cytotoxicity

Proceedings of the Society for Experimental Biology and Medicine
M RoyG Stotzky

Abstract

Selenium (Se) is an essential nutritional factor with a chemopreventive potential. This study examined the ability of C57BL/6J mice, maintained for 8 weeks on Se-deficient (0.02 ppm Se), normal (0.20 ppm Se), or Se-supplemented (2.00 ppm Se) Torula yeast-based diets, to generate cytotoxic lymphocytes (CTL) and to destroy tumor cells. CTL were generated in vivo by intraperitoneal immunization with P815 cells and in vitro by allogeneic stimulation of cells from animals maintained on a normal diet in media supplemented with 1 x 10(-9) to 1 x 10(-6) M Se (as selenite). Lymphocytes from animals maintained on the Se-supplemented diet had a greater ability to destroy tumor cells than lymphocytes from animals maintained on the normal diet, whereas Se deficiency reduced the cytotoxicity. The effects on cytotoxicity were accompanied by parallel changes in the levels of lymphotoxin produced. The greatest enhancement of tumor cytodestruction occurred with supplementation of 1 x 10(-7) M Se, whereas with 1 x 10(-6) M there was inhibition of the cytotoxic responses. The stimulatory effect of Se occurred during the phase of CTL generation rather than during the lytic phase of cytotoxicity. These results indicated that Se supplementation enhan...Continue Reading

Citations

Jun 1, 1996·Biological Trace Element Research·L Kiremidjian-SchumacherG Stotzky
Jan 1, 1996·Biological Trace Element Research·P BorellaC I Medici
Oct 1, 1993·Zentralblatt für Veterinärmedizin. Reihe A·L M SordilloJ Maddox
Feb 13, 2014·International Journal of Environmental Research and Public Health·Kejie ChenQingqiu Yang
Dec 11, 2013·Periodontology 2000·Dolphus R DawsonJeffrey L Ebersole
Jul 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kejie ChenWeimin Lai
Feb 3, 2016·Molecular Nutrition & Food Research·Naveena B JanakiramChinthalapally V Rao
Feb 25, 1999·Radiation Oncology Investigations·R SumarevaJ S Cooper
May 11, 2006·Integrative Cancer Therapies·Mark F McCarty, Keith I Block
Jul 15, 2005·European Journal of Clinical Nutrition·R KupkaW W Fawzi
Sep 1, 2007·Journal of Pediatric Hematology/oncology·Ilker Tolga OzgenSabri Acar
Apr 1, 1992·Biological Trace Element Research·L Kiremidjian-SchumacherG Stotzky

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