Selenium and thyroid

Best Practice & Research. Clinical Endocrinology & Metabolism
Josef Köhrle, Roland Gärtner

Abstract

Inadequate supply of the essential trace element selenium (Se) has been associated with predisposition for, or manifestation of, various human diseases such as Keshan and Kashin-Beck disease, cancer, impaired immune function, neurodegenerative and age-related disorders and disturbances of the thyroid hormone axis. Se deficiency in combination with inadequate iodine contributes to the pathogenesis of myxedematous cretinism. The recent identification of various distinct selenocysteine-containing proteins, encoded by 25 human genes, provides information on the molecular and biochemical basis of beneficial and possible adverse effects of this trace element. The thyroid gland is among the human tissues with the highest Se content per mass unit similar to other endocrine organs and the brain. Selenoproteins involved in cellular antioxidative defence systems and redox control, such as the glutathione peroxidase (GPx) and the thioredoxin reductase (TxnRd) family, are involved in protection of the thyroid gland from excess hydrogen peroxide and reactive oxygen species produced by the follicles for biosynthesis of thyroid hormones. In addition, the three key enzymes involved in activation and inactivation of thyroid hormones, the iodothy...Continue Reading

References

Feb 1, 1990·Biological Trace Element Research·J AasethY Thomassen
Jan 1, 1990·Annals of the New York Academy of Sciences·J E SpallholzH S Larsen
Dec 31, 1990·Biochemical and Biophysical Research Communications·D BehneJ Köhrle
May 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·R C Dickson, R H Tomlinson
Apr 1, 1994·Molecular and Cellular Endocrinology·J E DumontB Contempre
Feb 1, 1993·The American Journal of Clinical Nutrition·J B VanderpasJ E Dumont
Feb 1, 1993·The American Journal of Clinical Nutrition·D Behne, A Kyriakopoulos
Jun 1, 1993·The Journal of Clinical Investigation·J P ChanoineJ L Leonard
Mar 1, 1996·Biological Trace Element Research·G BermanoJ E Hesketh
Jan 1, 1996·Archives of Toxicology·V MakropoulosK Schulze-Osthoff
Aug 26, 1998·Immunology Today·R C McKenzieG J Beckett
Jul 14, 1999·Biochimie·J Köhrle
Mar 4, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J M ReimundB Duclos
Aug 30, 2000·Lancet·M P Rayman
Nov 15, 2000·Biological Chemistry·J KöhrlL Flohé
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M A BeckO A Levander
Oct 5, 2001·BioFactors·P ZagrodzkiM Słowiaczek
Mar 20, 2002·Methods in Enzymology·Josef Köhrle
Jun 12, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·J BrtkoJ Köhrle
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·B W KimA P Weetman
Mar 4, 2003·European Journal of Endocrinology·Hélène DerumeauxSerge Hercberg
Mar 27, 2003·European Journal of Endocrinology·Leonidas H DuntasDemetrios A Koutras
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Michał AmbroziakAlicja Nauman
Feb 6, 2004·BioFactors·Roland Gärtner, Barbara C H Gasnier
Oct 19, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mary E ReidJames R Marshall
Jul 7, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Roy MoncayoKlaus Kapelari
Aug 30, 2005·The Journal of Clinical Investigation·Ana Luiza MaiaP Reed Larsen
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Josef Köhrle
Sep 22, 2005·Endocrine Reviews·J KöhrleJ E Dumont
Oct 6, 2005·Biochemical and Biophysical Research Communications·Florian StreckfussUlrich Schweizer
Oct 18, 2005·Nature Genetics·Joanne E CurranJohn Blangero
Oct 18, 2005·Nature Genetics·Alexandra M DumitrescuSamuel Refetoff

❮ Previous
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Citations

Sep 14, 2011·Cell Biology and Toxicology·Iwona Zwolak, Halina Zaporowska
Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
Aug 24, 2010·Journal of Cardiovascular Pharmacology·Alex Sander da Rosa AraujoAdriane Belló-Klein
Dec 29, 2012·Thyroid Research·Małgorzata Karbownik-Lewińska, Agnieszka Kokoszko-Bilska
Jan 22, 2011·Environmental Health Perspectives·Karin BrobergMarie Vahter
May 10, 2013·International Journal of Nanomedicine·Kamel M A HassaninKhalid S Hashem
Aug 7, 2013·Research in Veterinary Science·Mohammad Ali Foroughi, Hesam Dehghani
Apr 21, 2010·Der Internist·J Köhrle, G Brabant
Feb 9, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mitra NourbakhshMaryam Razzaghy-Azar
Dec 25, 2015·European Journal of Endocrinology·Chantal ZevenbergenW Edward Visser
Mar 14, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mohammad Ali ForoughiMohammad Reza Bassami
Mar 1, 2012·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Pinar ErkekogluFiliz Hincal
Jan 17, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Glaecir Roseni Mundstock DiasNilda Berenice de Vargas Barbosa
Jan 12, 2012·Mutation Research·Lynnette R FergusonAlice H Wang
Jun 22, 2010·Toxicology·Nicholas V C Ralston, Laura J Raymond
Apr 3, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Véronique VacchinaRyszard Lobinski
Mar 2, 2010·Medical Hypotheses·Zongde YangMing Li
Oct 11, 2012·Clinical Endocrinology·Anne DrutelPhilippe Caron
Mar 2, 2013·Clinical Endocrinology·Inge Bülow PedersenPeter Laurberg
Jul 13, 2013·Clinical Endocrinology·Silvia A EskesWilmar M Wiersinga
Jul 1, 2015·Thyroid : Official Journal of the American Thyroid Association·Weiwei WangWeiping Teng
Apr 8, 2016·Biological Trace Element Research·Davut SakızMustafa Kulaksizoglu
Apr 16, 2014·Autism Research and Treatment·Laura J RaymondNicholas V C Ralston
Aug 30, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·C BertiI Cetin
Oct 2, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jan StępniakMałgorzata Karbownik-Lewińska
Oct 5, 2011·Nutrition·Yunfeng YaoPengde Kang
Sep 10, 2013·The Veterinary Journal·Mizuho UematsuTakeshi Osawa
Dec 19, 2014·Endocrine·Leonidas H Duntas, Salvatore Benvenga
Mar 24, 2012·Biochimica Et Biophysica Acta·Marina V KasaikinaVadim N Gladyshev
Jul 17, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Roland Gärtner
Apr 23, 2011·Annales d'endocrinologie·L H Duntas
Sep 13, 2016·Expert Opinion on Pharmacotherapy·Onyebuchi E Okosieme, John H Lazarus
Mar 3, 2017·BioFactors·Immacolata C NettorePaolo E Macchia
Apr 13, 2017·Environmental Geochemistry and Health·N MirleanO Vlasova
Jun 5, 2014·Biological Trace Element Research·Yang LiangShi-wen Xu
Oct 27, 2017·International Journal of Molecular Sciences·Bozena HosnedlovaRene Kizek
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Jan 8, 2019·Endocrine-related Cancer·Rabii Ameziane El HassaniCorinne Dupuy

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