PMID: 3456598Mar 1, 1986

Selenium and vitamin E inhibit radiogenic and chemically induced transformation in vitro via different mechanisms

Proceedings of the National Academy of Sciences of the United States of America
Carmia BorekJ E Biaglow

Abstract

Results from in vivo and in vitro studies showing that antioxidants may act as anticarcinogens support the role of active oxygen in carcinogenesis and provide impetus for exploring the functions of dietary antioxidants in cancer prevention by using in vitro models. We examined the single and combined effects of selenium, a component of glutathione peroxidase, and vitamin E, a known antioxidant, on cell transformation induced in C3H/10T-1/2 cells by x-rays, benzo[a]pyrene, or tryptophan pyrolysate and on the levels of cellular scavenging systems and peroxide destruction. Incubation of C3H/10T-1/2 cells with 2.5 microM Na2SeO3 (selenium) or with 7 microM alpha-tocopherol succinate (vitamin E) 24 hr prior to exposure to x-rays or the chemical carcinogens resulted in an inhibition of transformation by each of the antioxidants with an additive-inhibitory action when the two nutrients were combined. Cellular pretreatment with selenium resulted in increased levels of cellular glutathione peroxidase, catalase, and nonprotein thiols (glutathione) and in an enhanced destruction of peroxide. Cells pretreated with vitamin E did not show these biochemical effects, and the combined pretreatment with vitamin E and selenium did not augment the...Continue Reading

References

Sep 1, 1977·Cancer Letters·A C Griffin, M M Jacobs
Sep 8, 1978·Science·I Fridovich
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Kakunaga
Jan 1, 1991·Free Radical Research Communications·D K St Clair, L W Oberley
Dec 18, 1972·Annals of the New York Academy of Sciences·A L Tappel
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Carmia Borek, W Troll
Jun 24, 1980·Biochemistry·S A LeskoP O Ts'o
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R Zimmerman, P A Cerutti
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R Totter
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J K Dethmers, A Meister

Citations

Mar 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·T SakamotoS J Ryan
Jun 1, 1996·Digestive Diseases and Sciences·A R al-Moutairy, M Tariq
Jul 1, 1989·Biological Trace Element Research·M Sugiyama
Nov 14, 1986·Biochemical and Biophysical Research Communications·J ToskR Torrey
Jan 1, 1985·Pharmacology & Therapeutics·J E CleaverW F Morgan
Jan 1, 1988·Pharmacology & Therapeutics·J E BiaglowE P Clark
May 1, 1988·Mutation Research·R Menghini
Jan 1, 1992·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·J F WeissM R Landauer
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaM Tomassetti
Jan 1, 1988·Journal of Pharmaceutical and Biomedical Analysis·L CampanellaR Sbrilli
Jan 1, 1989·Free Radical Biology & Medicine·G A Pascoe, D J Reed
Jan 1, 1992·Free Radical Biology & Medicine·M Sugiyama
Jun 25, 2003·Toxicology·Joseph F Weiss, M R Landauer
Apr 8, 1998·Nutrition·K N PrasadP Hovland
Dec 31, 1997·Mutation Research·A AidooD A Casciano
Mar 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Carmia BorekA H Merrill
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R V CooneyL J Mordan
Nov 9, 2010·Nutrition and Cancer·Weimin GuoMohsen Meydani
Apr 4, 2003·Journal of the American College of Nutrition·K N PrasadWilliam C Cole
Jul 16, 1997·Journal of the National Cancer Institute·W L Stone, A M Papas
May 28, 1993·Annals of the New York Academy of Sciences·N I Krinsky
Jul 1, 1990·Environmental Health Perspectives·R G Stevens, D R Kalkwarf
Oct 1, 1993·Environmental Health Perspectives·Carmia Borek
Jan 18, 2006·Treatments in Respiratory Medicine·Melpo Christofidou-Solomidou, Vladimir R Muzykantov
Apr 14, 2011·Fukushima Journal of Medical Science·Yoshihisa TakahashiToshio Fukusato
Oct 1, 1994·The International Journal of Neuroscience·M TariqG W Bruyn
Jan 1, 1991·Free Radical Research Communications·Carmia Borek
Jun 27, 2009·International Journal of Radiation Biology·Joseph F Weiss, M R Landauer
Jul 27, 2011·Environmental Toxicology and Pharmacology·Dinesh Kumar Saini, Mali Ram Saini
Jan 1, 1988·Annals of the New York Academy of Sciences·Carmia Borek
Jan 1, 1988·Annals of the New York Academy of Sciences·Carmia Borek
Dec 17, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·C P LiuS Li
Jan 22, 2002·Nutrition and Cancer·R Gopalakrishna, U Gundimeda
Aug 2, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S SarnaR K Bhola
Nov 4, 2004·Integrative Cancer Therapies·Carmia Borek
Jul 1, 1988·American Journal of Health Promotion : AJHP·C L WallaceA A Watson
May 1, 1991·Environmental Health Perspectives·M Sugiyama
Jan 25, 2019·Current Pharmaceutical Design·B Poljsak, I Milisav
Feb 1, 1990·Journal of the American College of Nutrition·K N Prasad, J Edwards-Prasad
Aug 1, 1988·Journal of the American College of Nutrition·S N SahuK N Prasad
Oct 1, 1992·Journal of the American College of Nutrition·K N Prasad, J Edwards-Prasad
Mar 18, 2000·The Journal of Biological Chemistry·H S ParkE J Choi
May 10, 2000·The Journal of Biological Chemistry·B A WagnerC P Burns
Apr 14, 2009·Molecular and Cellular Biochemistry·Pavitra Ranawat, M P Bansal
Sep 1, 1987·Toxicology and Industrial Health·Carmia BorekH Mason
Jun 12, 2002·Journal of Radiation Research·Sudhir KapoorCherupally K Krishnan Nair
Sep 20, 2002·Journal of Radiation Research·Rema RajagopalanCherupally K Krishnan Nair
Jun 8, 2001·Journal of Radiation Research·C K NairT Nomura
Oct 30, 2004·The Journal of Nutrition·Carmia Borek
Sep 3, 2020·Journal of Animal Science·Randi N OwenSarah H White-Springer
Dec 1, 2006·Journal of Cosmetic Dermatology·K E Burke
Jan 21, 2021·Life·Anggraeini PuspitasariWalter Tinganelli

Related Concepts

Tryptophan pyrolysate
Metazoa
Benzo(a)pyrene
Beta-Carbolines
Catalase T
Neoplastic Cell Transformation
Reduced Glutathione
Selenoglutathione Peroxidase
Yb-Glutathione-S-Transferase
Peroxides

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