Selenium attenuates diclofenac-induced testicular and epididymal toxicity in rats.

Andrologia
Solomon E OwumiOyeronke A Odunola

Abstract

The adverse effect of diclofenac administration on the male reproductive organ in both humans and rats has been reported. Selenium, a trace element vital in nutrition, plays a significant part in cellular redox homeostasis, including male reproduction. However, the impact of selenium on male reproductive toxicity associated with diclofenac administration is lacking in the literature. The current investigation assessed the modulatory effects of selenium on diclofenac-mediated reproductive toxicity in rats. Rats were treated for fourteen consecutive days, either with diclofenac (10 mg/kg) or co-treated with selenium (0.125 and 0.25 mg/kg) body weight. Sperm parameters, enzymes of testicular function, luteinizing, follicle-stimulating hormone and testosterone were assessed in addition to oxidative stress indices and histopathological changes. Selenium significantly alleviated diclofenac-induced decreases in sperm count and motility, testicular function enzymes and levels of luteinizing hormone and testosterone in serum. Moreover, selenium co-administration at 0.125 and 0.25 mg/kg inhibited the diclofenac-induced decrease of antioxidant enzyme activities and increased oxidative stress parameters-lipid peroxidation, reactive nitroge...Continue Reading

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Citations

Jul 28, 2021·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Huimin QiuGuangli Hou
Sep 2, 2021·Biological Trace Element Research·Ruili ZhangXiaodan Huang
Nov 2, 2021·Journal of Biochemical and Molecular Toxicology·Solomon E OwumiIfeoluwa O Esan

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