PMID: 2484521Jan 1, 1988Paper

Selenium chemoprevention of liver cancer in animals and possible human applications

Biological Trace Element Research
S Y YuW G Li

Abstract

An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People's Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to aflatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by aflatoxin B1 was observed in lympocytes from human with Se-supplements.

References

Jun 1, 1980·Biological Trace Element Research·X ChenK Ge

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Citations

Jan 1, 1997·Biological Trace Element Research·S Y YuW G Li
Apr 1, 1989·Biological Trace Element Research·L OlmstedJ Dowd
Aug 10, 2007·Journal of the National Cancer Institute·Chen-Xu QuSanford M Dawsey
May 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·D Strauch, G Ballarini
Oct 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·J L BurgueraM Gallignani
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nataliya Rohr-UdilovaMarkus Peck-Radosavljevic
Feb 11, 2005·International Journal of Cancer. Journal International Du Cancer·Lori C SakodaKatherine A McGlynn
Aug 30, 2008·Molecular Nutrition & Food Research·Nagalakshmi Nadiminty, Allen C Gao
Jun 1, 1994·Chemico-biological Interactions·G N Schrauzer, J Sacher
Jan 1, 1995·Human & Experimental Toxicology·C Y ShiC N Ong
Feb 3, 2004·Journal of Cellular Biochemistry·Emmanuelle MeuilletMark A Nelson
Apr 1, 2014·The Cochrane Database of Systematic Reviews·Marco VincetiCinzia Del Giovane
Jan 30, 2018·The Cochrane Database of Systematic Reviews·Marco VincetiCatherine M Crespi
Mar 23, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Guo-Jian LiZhong-Liao Fang

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