PMID: 9417493Jan 7, 1998Paper

Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium

Medizinische Klinik
K HeinleO Adam

Abstract

Seventy patients with definitive rheumatoid arthritis were matched to built 2 groups, which were double-blind and randomized allocated to supplementation with sodium-selenit 200 micrograms/d or placebo for 3 months, each. Both groups were given fish oil fatty acids (30 mg/kg body weight), DMARDS were continued throughout the study, while variations in steroids or NSAD were admitted. Selenium concentrations in erythrocytes of patients with rheumatoid arthritis were 85.1 +/- 26 micrograms/l, and significantly lower than found in an average German population (123 +/- 23 micrograms/l). During the observation period of 3 months normal selenium concentrations were not restored, despite supplementation higher than RDA. At the end of the experimental period the selenium supplemented group showed less tender or swollen joints, and morning stiffness. Selen-supplemented patients needed less cortisone and NSAD than controls. In accordance with clinical improvement we found a decrease of laboratory indicators of inflammation (C-reactive protein, alpha 2-globuline, prostaglandin E2). No side effects of supplementation with selenium were noted, which can be considered as adjuvant therapy in patients with rheumatoid arthritis.

References

Apr 1, 1991·Seminars in Arthritis and Rheumatism·A M PeretzJ P Famaey
Feb 1, 1991·Annals of the Rheumatic Diseases·R D SitunayakeB McConkey
Jan 1, 1994·Annals of the Rheumatic Diseases·M HeliövaaraA Aromaa

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Citations

Aug 20, 2009·Zeitschrift für Rheumatologie·O AdamO Ditrich
Nov 4, 2004·The British Journal of Nutrition·Margaret P Rayman
Oct 17, 2018·Current Rheumatology Reviews·Maryam SahebariMandana Khodashahi
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Goran BjelakovicChristian Gluud
Jun 19, 2008·Wiener medizinische Wochenschrift·Olaf Adam
Oct 4, 2020·Nutrients·Francisco Javier Turrubiates-HernándezJosé Francisco Muñoz-Valle
Mar 29, 2003·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·K L RennieS A Jebb
Oct 1, 2005·Seminars in Arthritis and Rheumatism·Lisa K StampLeslie G Cleland
Jun 4, 2008·Best Practice & Research. Clinical Rheumatology·Margaret P Rayman, Dorothy J Pattison
Jul 29, 2008·The Science of the Total Environment·Miguel Navarro-Alarcon, Carmen Cabrera-Vique

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