Selenium-containing organic nanoparticles as silent precursors for ultra-sensitive thiol-responsive transmembrane anion transport

Nanoscale
Chao LangJunqiu Liu

Abstract

An anion transporter with a selenoxide group was able to form nanoparticles in water, whose activity was fully turned off due to the aggregation effect. The formed nanoparticles have a uniform size and can be readily dispersed in water at high concentrations. Turn-on of the nanoparticles by reducing molecules is proposed to be a combined process, including the reduction of selenoxide to selenide, disassembly of the nanoparticles and location of the transporter to the lipid membrane. Accordingly, a special acceleration phase can be observed in the turn-on kinetic curves. Since turn-on of the nanoparticles is quantitatively related to the amount of reductant, the nanoparticles can be activated in a step-by-step manner. Due to the sensibility of this system to thiols, cysteine can be detected at low nanomolar concentrations. This ultra-sensitive thiol-responsive transmembrane anion transport system is quite promising in biological applications.

References

Aug 13, 1992·Nature·C Higgins
Feb 19, 2005·Chemical Communications : Chem Comm·Beth A McNallyAnthony P Davis
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cameron C LeeFrancis C Szoka
Feb 1, 2007·Chemical Society Reviews·Thomas M Fyles
Feb 1, 2007·Chemical Society Reviews·Anthony P DavisBradley D Smith
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Aug 8, 2008·Nature Nanotechnology·Haifei ZhangSteven P Rannard
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Jan 15, 2009·Angewandte Chemie·Kristina RiehemannHarald Fuchs
May 9, 2009·Advanced Drug Delivery Reviews·Younsoo Bae, Kazunori Kataoka
Dec 22, 2009·Journal of the American Chemical Society·Ning MaXi Zhang
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hao-Li LiuKuo-Chen Wei
Nov 18, 2010·Archives of Biochemistry and Biophysics·Elizabeth A CowanSheldon W May
Feb 4, 2011·Angewandte Chemie·Wendelin J Stark
Mar 11, 2011·Chemical Society Reviews·Stefan MatileAndrea Fin
Jun 3, 2011·Journal of the American Chemical Society·Joshua I CutlerChad A Mirkin
Jun 21, 2012·Nature Communications·Andreas Vargas JentzschStefan Matile
Jul 19, 2012·Nature Communications·Xibin ZhouBing Gong
Nov 17, 2012·Chemical Communications : Chem Comm·Toshihide Takeuchi, Stefan Matile
Nov 20, 2012·Science·Martin LangeckerFriedrich C Simmel
Jan 4, 2013·Angewandte Chemie·Nathalie Busschaert, Philip A Gale
Feb 1, 2013·Journal of the American Chemical Society·Eun-Kyoung BangStefan Matile
Mar 23, 2013·Journal of the American Chemical Society·Andreas Vargas Jentzsch, Stefan Matile
Apr 16, 2013·Accounts of Chemical Research·Huaping XuXi Zhang
May 16, 2013·Journal of the American Chemical Society·Louis AdriaenssensPablo Ballester
Jan 22, 2014·Nanoscale·Joseph A Webb, Rizia Bardhan
Jun 28, 2014·Nanoscale·Guillaume BaffouHervé Rigneault
Jul 18, 2014·Nanoscale·D JaqueJ García Solé
Aug 15, 2014·Journal of the American Chemical Society·Hennie ValkenierAnthony P Davis
Nov 2, 2014·Journal of the American Chemical Society·Tatsuyuki YoshiiItaru Hamachi
Apr 23, 2015·Accounts of Chemical Research·Zhangrong LouKeli Han

❮ Previous
Next ❯

Citations

Jun 22, 2017·Chemical Communications : Chem Comm·Chao LangOfer Reany
Mar 27, 2019·Chemistry : a European Journal·Erdem SenolFranziska Schoenebeck
Jan 20, 2021·Chemistry : a European Journal·Javid Ahmad MallaPinaki Talukdar
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ariq AbdillahDavid G Churchill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.