Selenium Deficiency Downregulates Selenoproteins and Suppresses Immune Function in Chicken Thymus

Biological Trace Element Research
Pervez Ahmed KhosoShu Li

Abstract

Selenoproteins and selenium (Se) play important roles in the immune system. Selenoprotein expression in the immune system of mammals is sensitive to dietary Se levels; however, little is known about the expression of selenoproteins and their immune functions in the chicken thymus. We assessed selenoprotein gene expression and cytokine content in the chicken thymus in this study. The animals were randomly assigned to two groups as follows: the Se-deficient group (L group) was fed a diet containing 0.033 mg Se/Kg, and the control group was fed the same basal diet supplemented with Se at 0.15 mg/kg (sodium selenite). Real-time qPCR was used to investigate the expression level of selenoproteins on days 15, 25, 35, 45, and 55, and ELISA was used to evaluate the cytokine content on days 15, 35, and 55. The messenger RNA (mRNA) levels of Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, GPx1, GPx2, GPx3, Gpx4, Sepp1, Selo, Sep15, Sepx1, Sels, Seli, Selu, Selh, and SPS2 were all significantly decreased (P < 0.05) in the L group compared to the control group. A significant decrease in IL-2, IL-10, IL-17, IL-1β, IFN-α, and IFN-β was observed in the L group, and there was also a significant increase in IL-6, IL-8, IFN-γ, and TNF-α in the L group....Continue Reading

References

Apr 1, 1992·Biological Trace Element Research·L Kiremidjian-SchumacherG Stotzky
May 1, 1997·Protein Science : a Publication of the Protein Society·R J SimpsonL D Ward
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·H Y YehJ M Sharma
May 16, 2002·The British Journal of Nutrition·Maxine BonhamJ J Strain
Jul 20, 2002·Progress in Neurobiology·Chen Xu Wang, Ashfaq Shuaib
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dennis M HintonMing W Chou
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Mar 3, 2004·Archives of Biochemistry and Biophysics·Regina Brigelius-FlohéGaby-Fleur Böl
Sep 10, 2005·Developmental and Comparative Immunology·Basavarajappa N HangalapuraSusan J Lamont
Mar 1, 2006·The Journal of Experimental Medicine·Timothy S OlsonTheresa T Pizarro
May 30, 2006·Nature Medicine·Mihai G NeteaJos W M van der Meer
Aug 1, 2006·Journal of Inorganic Biochemistry·John LoflinChrissa Kioussi
Jan 11, 2007·Biochemical and Biophysical Research Communications·Kee-Hong KimAhmed H Kissebah
May 22, 2007·The Journal of Nutrition·Patricia A SheridanMelinda A Beck
Jan 26, 2008·Archivum Immunologiae Et Therapiae Experimentalis·Peter R Hoffmann
Jul 1, 2008·Allergy·P R Hoffmann
Sep 16, 2008·The Journal of Nutritional Biochemistry·Jinhong ZengKaixun Huang
Sep 16, 2008·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A C PappasG Zervas
Mar 17, 2009·Biochimica Et Biophysica Acta·Alain LescureValérie Allamand
May 24, 2011·Biological Trace Element Research·Xi PengWeimin Lai
Apr 6, 2012·PloS One·Marco MariottiVadim N Gladyshev
May 16, 2012·Biological Trace Element Research·Zi-wei ZhangShi-wen Xu
Jan 22, 2013·Biochimica Et Biophysica Acta·Hai-Dong YaoShi-Wen Xu
Feb 27, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zi-wei ZhangShi-wen Xu
Dec 10, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Peng-Fei ShengShi-Wen Xu
Jan 15, 2014·Chemico-biological Interactions·Ci LiuShu Li
Jun 5, 2014·Biological Trace Element Research·Yang LiangShi-wen Xu
Oct 17, 2014·Biological Trace Element Research·Xia ZhaoShiwen Xu

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Citations

Mar 24, 2016·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
Oct 7, 2015·Biological Trace Element Research·Jinxin ZhaoShiwen Xu
Jun 22, 2016·Animal Science Journal = Nihon Chikusan Gakkaihō·Jiayong TangHua Zhao
Oct 17, 2016·Biological Trace Element Research·Pervez Ahmed KhosoShu Li
May 15, 2018·Antioxidants·Evangelos ZoidisGeorgios P Danezis
Jan 6, 2018·Biological Trace Element Research·Yachao WangXuegang Luo
Jun 21, 2019·Biological Trace Element Research·Jianwen XuZiwei Zhang
Jun 9, 2019·Journal of Neurodevelopmental Disorders·Zahra MotahariAnthony-Samuel LaMantia
Sep 15, 2018·Journal of Animal Science and Biotechnology·Marco ZampigaFederico Sirri
Nov 6, 2018·Biological Trace Element Research·Erhui JinShenghe Li
Jul 2, 2019·Biomedit︠s︡inskai︠a︡ khimii︠a︡·N Y RusetskayaV B Borodulin
Jul 28, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Nan CaoDanning Xu
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jian WuQiuhui Hu

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