Selenium deficiency-induced redox imbalance leads to metabolic reprogramming and inflammation in the liver.

Redox Biology
Chaohua TangJunmin Zhang

Abstract

Selenium (Se) intake disequilibrium is associated with many human diseases (e.g., Keshan disease and type 2 diabetes). To understand the mechanism of Se deficiency-induced hepatic pathogenesis, a pure line pig model was established by feeding a diet with either 0.07 mg/kg Se or 0.3 mg/kg Se for 16 weeks. The hepatic metabolome, lipidome, global proteome, and whole transcriptome were analyzed. Se deficiency causes a redox imbalance via regulation of selenoproteins at both the mRNA and protein level, and blocks the glutathione anti-oxidant system along with enhanced glutathione synthesis and catabolism. The Warburg effect was observed by enhanced activation of the glycolysis and phosphate pentose pathways. The tricarboxylic acid cycle was dysfunctional since the preliminary metabolites decreased and shifted from using glycolysis origin substrates to a glutamine catabolism-preferred metabolic mode. The reprogrammed central carbon metabolism induced widely restrained lipid synthesis. In addition, a Se deficiency initiated inflammation by activating the NF-κB pathway through multiple mechanisms. These results identified the potential metabolic vulnerability of the liver in response to a Se deficiency-induced redox imbalance and poss...Continue Reading

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Citations

Nov 28, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Zhuo-Zhi LiangZe-Fang Ren
Jun 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shao-Shuai BiJin-Long Li
Dec 22, 2021·Molecular Nutrition & Food Research·Chaohua TangJunmin Zhang

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Methods Mentioned

BETA
electrophoresis
PCR
reverse phase chromatography
Illumina sequencing
MDA
PCA
acetylation

Software Mentioned

Metaboanalyst
light
Metascape
R
Lipidsearch
Cytoscape
RNAhybrid
circ
Mireap
find

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