Selenium effects on human neutrophilic granulocyte function in vitro

Immunopharmacology
T Urban, C Jarstrand

Abstract

The effects of an inorganic selenium salt on phagocytic functions of human neutrophilic granulocytes from donors with a low activity of glutathione peroxidase have been investigated. Granulocytes were exposed for 60 min in vitro to sodium selenite in two physiological concentrations (100 and 200 ng Se/ml) and one unphysiologically high concentration (2000 ng/ml). The spontaneous and chemotactic migration, the nitroblue tetrazolium reduction, the phagocytosis of fluorescein-labeled yeast particles and the intracellular killing of staphylococci were then studied in such granulocytes and compared to control cells, which had not been exposed to selenium. The migration and nitroblue tetrazolium reduction abilities of granulocytes were not affected by selenium exposure. The phagocytic and bactericidal activities were significantly increased in granulocytes exposed to selenium in physiological concentrations. However, at 2000 ng Se/ml these activities were found to be equal to or lower than control levels. Thus selenium supplementation might enhance phagocytic and bactericidal functions of human granulocytes, thereby improving the host defense against bacterial infections.

References

Mar 23, 1978·The New England Journal of Medicine·B M Babior
Dec 15, 1978·Experientia·S Kelly, L Schedlbauer
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
May 2, 1968·The New England Journal of Medicine·R L Baehner, D G Nathan
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·R O MulhausenK Mellemgaard
Jul 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·J E BlalockH M Johnson
Apr 1, 1981·Journal of Comparative Pathology·R Boyne, J R Arthur
May 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·M S Barkley, G E Bradford
May 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·J C PenhosP Ramwell
Dec 1, 1983·Biological Trace Element Research·J Steven MorrisW Willett

❮ Previous
Next ❯

Citations

Apr 1, 1989·Biological Trace Element Research·L OlmstedJ Dowd
May 1, 1990·Immunopharmacology·M P Nair, S A Schwartz
Nov 6, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Alexandra Paiva AraújoGeorge Luiz Lins Machado-Coelho
Aug 17, 2000·The Journal of Infectious Diseases·K L EricksonN E Hubbard
Oct 5, 2010·Seminars in Pediatric Surgery·Robin C Cook, Thane A Blinman
Jan 7, 1998·Medizinische Klinik·R GärtnerJ Schottdorf
Apr 1, 1991·Seminars in Arthritis and Rheumatism·A M PeretzJ P Famaey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.