Selenium-Enriched Saccharomyces cerevisiae Reduces the Progression of Colorectal Cancer

Biological Trace Element Research
Jamileh AbediAhmad Yari Khosroushahi

Abstract

Colorectal cancer is one of the most common causes of mortality in the world while malnutrition is responsible for one third of the problem. Selenium has been recommended for prevention of colorectal cancer. The present study was conducted to investigate the effect of selenium-enriched Saccharomyces cerevisiae in reducing colorectal cancer progression in rats. Five groups of 170-200-g weight rats (n = 40) including healthy and cancer controls, Saccharomyces cerevisiae, selenium, and selenium-enriched Saccharomyces cerevisiae-treated groups were examined. All animals except healthy control group received 40 mg 1,2-dimethylhydrazine (DMH) per kilogram weight of rat twice a week. The healthy group received normal saline, and synchronously, selenium group received soluble selenium (4 mg/mL), Saccharomyces cerevisiae and selenium-enriched groups received yeast with the density of 5 × 108 CFU/mL by daily gavage. All treatments were carried out for 5 weeks after the last injection. Animals were autopsied, and aberrant crypt foci (ACF) of ejected colon were studied in the 40th week. Microscopic sections were prepared for hematoxylin and eosin. Furthermore, immunohistochemical staining of CD31, BCL2, and P53 antibodies was performed. Ma...Continue Reading

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Citations

Mar 25, 2019·Biological Trace Element Research·Li JiangZhao-Jun Wei
Jun 30, 2019·Oxidative Medicine and Cellular Longevity·Yiming ZhangShu Li
Mar 14, 2019·Frontiers in Microbiology·Yousef NamiMohammad Amin Hejazi
Apr 21, 2018·Biological Trace Element Research·Marek KieliszekAnna M Kot
Dec 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Xiali QinHailong Cao
Mar 12, 2021·The Journal of Nutritional Biochemistry·Juncheng LiuXinchun Shen
Jul 3, 2021·Cancers·Natalia VallianouMaria Dalamaga
Mar 11, 2021·Probiotics and Antimicrobial Proteins·Sabna BsJayaraman Angayarkanni
Dec 19, 2021·Journal of the Science of Food and Agriculture·Feifei SongJunzhi Qiu

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