PMID: 2484511Jan 1, 1988Paper

Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States

Biological Trace Element Research
M L Jackson

Abstract

The geochemistry of available soil Se varies enormously in different localities, and the corresponding amounts moving up through crops to food vary accordingly. In a belt extending from northeastern to south central China, the available soil Se was measured by human blood Se levels. Severe deficiency occurred at 8-26 ng/mL; subadequate amounts occurred in large areas with 32-83 ng/mL; adequate amounts of 200-300 ng/mL occurred in large cities; and toxic amounts of 3000-7800 ng/mL occurred in terrace areas where runoff from the uplands evaporated, and in certain other soils. Some heart deaths (Keshan Disease) occurred in children 1 to 10 yr of age in the most deficient areas, but were prevented by 230-900 micrograms/wk Se supplementation. One mg Se/wk was the adult dosage. In Se deficient areas, the life span of adults was lowered severely (35 to 45 yr), with heart muscle damage common at autopsy. Se and Zn deficiencies are apparently associated with stomach cancer. The geochemistry of Se in the USA is also highly variable, blood Se ranging from 100-350 ng/mL. Se data for individuals are limited; however, ischemic heart death correlated inversely with blood Se in 25 cities of 22 states (r = -.70; p less than .01). Counties of Wi...Continue Reading

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Citations

Aug 1, 1996·Biological Trace Element Research·K MengübaşS Cin
Mar 1, 1994·Biological Trace Element Research·M VincetiG Vivoli
Apr 1, 2003·Environmental Toxicology and Pharmacology·M Kürsad TürkdoğanIsmail Uygan
Feb 3, 2004·Journal of Cellular Biochemistry·Emmanuelle MeuilletMark A Nelson
Jan 31, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·G BellisolaG Guidi
Sep 1, 1995·Archives of Environmental Health·H NakadairaK Katoh
Nov 21, 2007·The British Journal of Nutrition·Noel W Solomons
Apr 30, 2013·Biological Trace Element Research·Yuan LiuLinsheng Yang
Oct 27, 2017·Anais Da Academia Brasileira De Ciências·Jairo J ZoccheVanessa M DE Andrade
Aug 24, 2019·Journal of Molecular Biology·Janinah BaclaocosJohn F Atkins

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