PMID: 2484516Jan 1, 1988Paper

Selenium in chronic neurologic diseases. Multiple sclerosis and Batten's disease

Biological Trace Element Research
J ClausenS A Nielsen

Abstract

The selenium levels in whole blood and the activity of glutathione peroxidase in hematogenous cells of normal Danes have been defined taking into account sex and confounding factors such as smoking and aging. No differences related to sex could be found with regard to the selenium level, and peroxidase activity assayed with hydrogen peroxide. However, the peroxidase activity assayed with t-butyl hydroperoxide was higher in females than in males (p less than .05). The peroxidase activities are dependent on age. Thus, the peroxidase levels assayed with both substrates show a minimum value in the age group from 40 to 50 yr for both smokers and nonsmokers. Smokers did show more homogeneous values as a function of age than nonsmokers. Smokers had significantly lower selenium values than nonsmokers, but glutathione peroxidase values identical with those of nonsmokers. Multiple sclerosis (MS) patients suffer from a chronic relapsing/remitting demyelinating disease. A theory explaining the pathogenesis of MS concerns increased stickiness of cellular plasma membranes, hampering normal vascular function of the brain. In agreement with that theory, the present communication demonstrates significantly lowered selenium values and lowered gl...Continue Reading

References

Jun 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·G E JensenJ Clausen
Nov 1, 1976·Toxicology·S C RastogiK C Srivastava
Jan 1, 1975·Perspectives in Biology and Medicine·H S Mickel
Feb 1, 1985·Acta Neurologica Scandinavica·P SantavuoriU Vuonnala
May 23, 1981·Lancet·R H Dworkin
Jul 29, 1983·Biochemical and Biophysical Research Communications·W Jubiz, G Nolan
Nov 1, 1984·Acta Neurologica Scandinavica·J Clausen
May 1, 1980·Neuropathology and Applied Neurobiology·R D JollyI Morrison
Feb 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·J J Dougherty, W G Hoekstra

❮ Previous
Next ❯

Citations

Jun 5, 1995·American Journal of Medical Genetics·L Black, R K Pullarkat
Mar 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Stefan Schwarz, Hans Leweling
Apr 10, 2015·PloS One·Elisa TamburoLuigi Maria Edoardo Grimaldi
Oct 4, 2015·Nutrition Reviews·Amene SaghazadehNima Rezaei
Oct 1, 1994·The International Journal of Neuroscience·M TariqG W Bruyn
Oct 24, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gail Shor-PosnerMaria-Jose Miguez-Burbano
Dec 8, 2004·Der Nervenarzt·S Schwarz, H Leweling
Aug 1, 1996·Biological Trace Element Research·K MengübaşS Cin
Jun 17, 2003·Journal of Neurochemistry·Jun Chen, Marla J Berry
Oct 17, 2018·Current Rheumatology Reviews·Maryam SahebariMandana Khodashahi
Mar 12, 2010·Mechanisms of Ageing and Development·Shu ZhangWen-Hsing Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Batten Disease

Batten Disease is a group of nervous system disorders known as neuronal ceroid lipofuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease.