Selenium in Complicated Pregnancy. A Review

Advances in Clinical Chemistry
Bronislaw A Zachara

Abstract

Selenium (Se) is an essential trace element of significant importance in human health. Diet is the major source of Se, and intake of this element depends on its concentration in food sources as well as the amount of those sources consumed. Unfortunately, daily dietary intake of Se in most European countries is generally low, ∼30-40μg/day, compared with the recommended dietary allowance, ∼55 and 70μg/day for adult females and males, respectively. The importance of Se as an essential trace element is linked to its role as selenocysteine in a number of selenoproteins including antioxidant enzymes glutathione peroxidases (GSH-Pxs), thioredoxin reductases (TrxRs), and selenoprotein P (SePP). These enzymes protect tissues against the damaging effect of reactive oxygen species (ROS) and other endogenous products of cellular metabolism implicated in DNA damage and potentially leading to mutagenesis, cell death, and carcinogenesis. Reduced body Se and antioxidant enzyme activity during pregnancy results in oxidative stress within tissues contributing to premature birth, miscarriage, preeclampsia, and intrauterine growth retardation. Because placenta development is highly dependent on oxygen status, uncontrolled ROS formation is likely d...Continue Reading

Citations

Apr 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonas ZauggChristiane Albrecht
Jan 31, 2020·Clinical and Experimental Pharmacology & Physiology·Roberto Laureano-MeloWellington S Côrtes
Sep 19, 2019·International Journal of Environmental Research and Public Health·Keith Schofield
Jun 30, 2019·Nutrients·Sohayla A Z IbrahimAbdelali Agouni
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Oct 6, 2020·Thyroid Research·Leonidas H Duntas
Oct 9, 2020·Nutrients·Ksenija Ogrizek PelkičIztok Takač
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Jul 28, 2020·ACS Omega·Sergey V GudkovValery P Kalinitchenko

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