PMID: 9417502Jan 7, 1998Paper

Selenium in peroxide metabolism

Medizinische Klinik
L Flohé

Abstract

Out of the growing number of so far known mammalian selenoproteins four are peroxidases. Their common catalytic mechanism involves redox shuttling of a selenocysteine residue in the active site, where it forms a characteristic catalytic triad with hydrogen-bonded tryptophan and glutamine residues. These peroxidases differ in tissue distribution, substrate specificity, regulation, responsiveness to selenium restriction, and likely in their biological role. Cytosolic glutathione peroxidase, which predominates in balancing hydroperoxide toxicity, rapidly declines in selenium deficiency. Prophylactic selenium supplementation is considered reasonable also in asymptomatic moderate selenium deficiency whenever a clinical condition known to cause oxidative stress has to be anticipated.

References

May 15, 1973·FEBS Letters·L FloheH H Schock
Jan 1, 1995·Methods in Enzymology·F UrsiniL Flohé
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Tamura, T C Stadtman
Jan 1, 1997·Free Radical Biology & Medicine·L FlohéL Packer
Jan 1, 1997·BioFactors·P SteinertL Flohé

❮ Previous
Next ❯

Citations

Nov 11, 1999·Medizinische Klinik·U M SchleicherJ Ammon
Nov 15, 2011·Journal of Bacteriology·Nicholas NoinajSusan K Buchanan
Nov 11, 1999·Medizinische Klinik·J BörnerD Roesner
Jul 11, 2002·Free Radical Biology & Medicine·Hartmut Kühn, Astrid Borchert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.