PMID: 2484525Jan 1, 1988Paper

Selenium in the anterior pituitary of the rat after a single injection of 75Se sodium selenite

Biological Trace Element Research
O Thorlacius-Ussing, F T Jensen

Abstract

In order to investigate the selenite metabolism in the anterior pituitary and compare it with other endocrine organs, rats were injected intraperitoneally with 75Se sodium selenite (5 mg/kg). The rats were whole body counted shortly after injection and recounted just before sacrifice, which was performed 2, 24, 48 h, and 4, 10, 20, 30, 40, 60, and 80 d after injection. Besides the anterior pituitary, the selenium content was also estimated in the thyroid gland, testis, adrenals, liver, kidney, and blood. The maximum selenium content was observed in all organs 2 h after injection, at which time the anterior pituitary contained 2.9 micrograms/g wet wt, compared to 13.5 micrograms/g wet wt in liver and .6 micrograms/mg wet wt in testis. The excretion of selenite from the anterior pituitary resembled that seen in most other organs investigated, i.e., an initial rapid excretion and a slower secondary phase resembling a first order reaction. Practically all selenium was excreted by 60 d after injection. The selenium content in pituitaries from untreated rats was estimated by PIXE analysis to be 2.2 +/- .1 micrograms dry wt and .48 +/- .03 micrograms/g wet wt. From the present study it can be concluded that selenium in the form of sel...Continue Reading

References

Nov 15, 1979·Biochimica Et Biophysica Acta·K P McConnellP J Higgins
Sep 1, 1986·The Journal of Nutrition·M A Beilstein, P D Whanger
Mar 1, 1987·Neuroendocrinology·O Thorlacius-Ussing
Feb 1, 1987·Journal of Inorganic Biochemistry·M A Beilstein, P D Whanger
Sep 1, 1986·The Journal of Nutrition·M A Beilstein, P D Whanger
Oct 1, 1985·Toxicology and Applied Pharmacology·O Thorlacius-Ussing, G Danscher
Jul 1, 1973·The British Journal of Nutrition·C D Thomson, R D Stewart
Jan 1, 1973·The Journal of Nutrition·D G Brown, R F Burk
Mar 1, 1974·The Journal of Nutrition·I S Palmer, O E Olson
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·S A GunnW A Anderson
Apr 1, 1967·The Journal of Nutrition·R C EwanC A Baumann
Jan 1, 1982·Drug Metabolism Reviews·B A BoppJ W Kesterson
Nov 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·I ROSENFELD, O A BEATH
Aug 1, 1985·Biological Trace Element Research·E B ThorlingA Foldspang

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Citations

Nov 1, 1992·Biological Trace Element Research·H Grønbaek, O Thorlacius-Ussing
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H Grønbaek, O Thorlacius-Ussing
May 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·M A Tariq, I L Preiss
Sep 22, 2005·Endocrine Reviews·J KöhrleJ E Dumont
Jun 19, 2013·Biological Trace Element Research·Nadezdha L Basalaeva

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