Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum

Neurochemistry International
Perla D MaldonadoAbel Santamaría

Abstract

Selenium (Se) is a crucial element exerting antioxidant and neuroprotective effects in different toxic models. It has been suggested that Se acts through selenoproteins, of which thioredoxin reductase (TrxR) is relevant for reduction of harmful hydroperoxides and maintenance of thioredoxin (Trx) redox activity. Of note, the Trx/TrxR system remains poorly studied in toxic models of degenerative disorders. Despite previous reports of our group have demonstrated a protective role of Se in the excitotoxic/pro-oxidant model induced by quinolinic acid (QUIN) in the rat striatum (Santamaría et al., 2003, 2005), the precise mechanism(s) by which Se is inducing protection remains unclear. In this work, we characterized the time course of protective events elicited by Se as pretreatment (Na(2)SO(3), 0.625 mg/kg/day, i.p., administered for 5 consecutive days) in the toxic pattern produced by a single infusion of QUIN (240 nmol/μl) in the rat striatum, to further explore whether TrxR is involved in the Se-induced protection and how is regulated. Se attenuated the QUIN-induced early reactive oxygen species formation, lipid peroxidation, oxidative damage to DNA, loss of mitochondrial reductive capacity and morphological alterations in the st...Continue Reading

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Citations

Apr 12, 2014·Oxidative Medicine and Cellular Longevity·Daniela Silva-AdayaJorge Guevara
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Antonio AyalaSandro Argüelles
Oct 4, 2013·Oxidative Medicine and Cellular Longevity·Rafael Lugo-HuitrónVerónica Pérez-de la Cruz
Aug 25, 2016·Anais Da Academia Brasileira De Ciências·Joel H EllwangerJoão A P Henriques
Dec 3, 2016·Anais Da Academia Brasileira De Ciências·Patrícia F Schuck
Oct 17, 2019·BioFactors·Desirée BartoliniGavin Y Wang
Feb 20, 2021·Redox Biology·Viktoria K WandtTanja Schwerdtle
Oct 8, 2021·Biological Trace Element Research·Elham BakhtiariMohammad Heidarian

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