Selenium intake and cardiovascular risk: what is new?

Current Opinion in Lipidology
Ana Navas-AcienEliseo Guallar

Abstract

Selenium is an essential element with a narrow safety margin. Adequate selenium intake is needed to maximize the activity of glutathione peroxidases and other selenoproteins. This review discusses recent experimental and epidemiologic contributions on the role of selenium for the prevention of atherosclerotic cardiovascular disease. Few randomized trials have evaluated the efficacy of selenium supplementation on cardiovascular endpoints. Most trials, conducted in selenium-replete populations, found no evidence of cardiovascular protection. A meta-analysis of 13 prospective cohort studies found a moderate inverse relationship between plasma/serum selenium and coronary heart disease. The interpretation of these data is complicated, however, by potential residual confounding and publication bias. In contrast, recent data from trials of selenium-containing supplements and from epidemiologic studies suggest that chronically increased selenium intake in selenium-replete populations can induce diabetes and maybe also hypercholesterolemia. Current evidence is insufficient to support a protective role for selenium in cardiovascular prevention. Large high-quality randomized controlled trials and observational studies are needed across po...Continue Reading

References

Dec 15, 1995·The American Journal of Cardiology·S SalviniM J Stampfer
Jul 1, 1994·Free Radical Biology & Medicine·J E Spallholz
Oct 28, 1999·The American Journal of Clinical Nutrition·A J DuffieldS Williams
Aug 30, 2000·Lancet·M P Rayman
May 12, 2001·The British Journal of Nutrition·G F Combs
Jul 4, 2001·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·W C YouG W Xu
Jan 5, 2002·The New England Journal of Medicine·B G BrownJ J Albers
Jul 24, 2002·Nutrition in Clinical Care : an Official Publication of Tufts University·Raymond F Burk
Mar 31, 2004·Biological Trace Element Research·Qingzhi Wu, Kaixun Huang
Jun 26, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Mahmoud ZureikSerge Hercberg
Jan 20, 2005·Journal of the National Cancer Institute·Scott M LippmanCharles A Coltman
Apr 9, 2005·The American Journal of Clinical Nutrition·Yiming XiaRaymond F Burk
Aug 12, 2005·Journal of the American College of Nutrition·Swapnil RajpathakFrank Hu
Nov 30, 2005·The Proceedings of the Nutrition Society·Margaret P Rayman
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Raymond F BurkDaniel W Byrne
Aug 10, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James R MarshallE David Crawford
Oct 7, 2006·The American Journal of Clinical Nutrition·Gemma Flores-MateoEliseo Guallar
Oct 7, 2006·The American Journal of Clinical Nutrition·Joachim BleysEliseo Guallar
Oct 24, 2006·Biological Trace Element Research·Qingzhi Wu, Kaixun Huang
Jan 24, 2007·European Heart Journal·Tim S NawrotHarry A Struijker-Boudier
Mar 30, 2007·Diabetes Care·Joachim BleysEliseo Guallar
May 19, 2007·Antioxidants & Redox Signaling·Laura Vanda PappKum Kum Khanna
Jul 11, 2007·Annals of Internal Medicine·Saverio StrangesMary E Reid
Jul 11, 2007·Annals of Internal Medicine·Joachim BleysEliseo Guallar

❮ Previous
Next ❯

Citations

Feb 27, 2008·Archives of Internal Medicine·Joachim BleysEliseo Guallar
Apr 14, 2010·European Journal of Nutrition·S LetsiouC Stefanadis
Sep 14, 2011·Cell Biology and Toxicology·Iwona Zwolak, Halina Zaporowska
Nov 24, 2011·Journal of Exposure Science & Environmental Epidemiology·Ellen M WellsFrank R Witter
Sep 19, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jennifer LockeNeil Fleshner
Sep 4, 2010·Antioxidants & Redox Signaling·Susan J Fairweather-TaitRachel Hurst
Dec 19, 2008·International Journal of Epidemiology·Wasim Maziak
May 11, 2012·Journal of Hypertension·Heiner K BertholdIoanna Gouni-Berthold
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Martin LaclaustraEliseo Guallar
Nov 13, 2009·The Journal of Nutrition·Saverio StrangesEliseo Guallar
Apr 18, 2013·Public Health Nutrition·Dulanji KuruppuSujuan Gao
Jun 27, 2014·Journal of Developmental Origins of Health and Disease·E M WellsL R Goldman
Sep 30, 2014·Archives of Gerontology and Geriatrics·Chen ChenSujuan Gao
Apr 30, 2015·Nutrients·Carina BenstoemChristian Stoppe
Jul 25, 2012·Environmental Toxicology and Pharmacology·Paweł GaćKrystyna Pawlas
Jan 5, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J ArnaudUNKNOWN European Collaborative Group of the IMMIDIET Project
Nov 26, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S StrangesE Guallar
Mar 31, 2009·Biochimica Et Biophysica Acta·Lutz Schomburg, Ulrich Schweizer
Jul 29, 2008·The Science of the Total Environment·Miguel Navarro-Alarcon, Carmen Cabrera-Vique
Jul 5, 2012·Molecular Nutrition & Food Research·Stéphane TanguyFrançois Boucher
May 31, 2011·Archives of Biochemistry and Biophysics·FuKun W HoffmannPeter R Hoffmann
Dec 17, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Urban Alehagen, Jan Aaseth
Nov 5, 2013·Metallomics : Integrated Biometal Science·Marco RomanCarlo Barbante
Oct 27, 2016·Biological Trace Element Research·Klaus HäfeleinBodo Kurz
Dec 24, 2016·Metallomics : Integrated Biometal Science·Hongmei LiuKaixun Huang
Sep 19, 2015·PloS One·Liqin SuYinlong Jin
Nov 5, 2010·The American Journal of Clinical Nutrition·Maria WennbergJan-Håkan Jansson
Nov 14, 2019·International Journal of Molecular Sciences·Natasa CvetinovicJerneja Farkas
Aug 12, 2008·The American Journal of Clinical Nutrition·Joachim BleysEliseo Guallar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.