Selenium nanoparticles induce suppressed function of tumor associated macrophages and inhibit Dalton's lymphoma proliferation

Biochemistry and Biophysics Reports
Pramod Kumar GautamB Ram

Abstract

Selenium Nanoparticle (SeNPs) is reported that it enhances and maintains optimal immune during infection and malignancies. To this end, we examined the role of selenium on TAMS whose anti-tumor function suppressed which favor tumor progression. BALB/c (H2d) strain of mice non-Hodgkin type of Dalton's cell line was used to check the role of carboxlic group induced, synthesized SeNPs on TAMs. Screening of IC50 value was done primarily trypen blue exclusion assay and 50% proliferation of DL cells inhibited 40 ng/ml to 50 ng/. Treatment also decreases ΔΨm, fragmentation of DNA of DL cells and arrest cells cycle in G1/G0 phage. Untreated TAMs cells showing suppressed expression of ROS, adhesion, phagocytosis, fusion and receptor profiling such as ICAM-1, CD47, CD172α. Which was induced more as compare to untreated group. SeNPs have potential to induce the anti-tumor function of TAMs whose anti-tumor function down-regulated pliable shifted towards tumor progression. It decreased the proliferation of DL cell by inducing apoptosis. Therefore, the synthesized SeNPs could be used for imaging diagnosis and cancer therapy which must be cost effective with negligible side effects shifted towards tumor progression. It decreased the prolifera...Continue Reading

Citations

Jun 18, 2019·Chemistry : a European Journal·Wen FuXue-Feng Yu
Jan 31, 2020·Critical Reviews in Biochemistry and Molecular Biology·Fenghua QianK Sandeep Prabhu
May 20, 2020·Frontiers in Oncology·Marina SerraAlessio Menga
Sep 12, 2018·Nutrients·Joseph C Avery, Peter R Hoffmann
Jan 3, 2021·Biological Trace Element Research·Amr Hosny HashemSalem S Salem
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Aug 17, 2021·Frontiers in Pharmacology·Wensen LinJiang Pi

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Methods Mentioned

BETA
protein folding
PMA
light microscopy
Flowcytometry
lavage
scanning electron microscopy
ELISA
transmission
electron diffraction
flow cytometry

Software Mentioned

Sigma Plot

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