Selenium Nanoparticles Induce the Chemo-Sensitivity of Fluorouracil Nanoparticles in Breast and Colon Cancer Cells

Biological Trace Element Research
Ahmed A Abd-RabouHanaa H Ahmed

Abstract

Drug resistance is a major challenge of breast and colon cancer therapies leading to treatment failure. The main objective of the current study is to investigate whether selenium nanoparticles (nano-Se) can induce the chemo-sensitivity of 5-fluorouracil (FU)-encapsulated poly (D, L-lactide-co-glycolide) nanoparticles (nano-FU) in breast and colon cancer cell lines. Nano-Se and nano-FU were synthesized and characterized, then applied individually or in combination upon MCF7, MDA-MB-231, HCT 116, and Caco-2 cancerous cell lines. Cytotoxicity, cellular glucose uptake, and apoptosis, as well as malondialdehyde (MDA), nitric oxide (NO), and zinc (Zn) levels, were investigated upon the different treatments. We have resulted that nano-FU induced cell death in MCF7 and Caco-2 more effectively than MDA-MB-231 and HCT 116 cell lines. Moreover, nano-FU plus nano-Se potentiate MCF7 and Caco-2 chemo-sensitivity were higher than MDA-MB-231 and HCT 116 cancerous cell lines. It is relevant to note that Se and FU nano-formulations inhibited cancer cell bioenergetics via glucose uptake slight blockage. Furthermore, nano-FU increased the levels of NO and MDA in media over cancer cells, while their combinations with nano-Se rebalance the redox sta...Continue Reading

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Citations

Dec 27, 2018·International Journal of Molecular Sciences·Heng Wee TanYan-Ming Xu
Mar 8, 2020·Inflammopharmacology·Sneha Hariharan, Selvakumar Dharmaraj
May 9, 2019·Biological Trace Element Research·Ahmed A Abd-RabouAziza B Shalby
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Aug 17, 2021·Frontiers in Pharmacology·Wensen LinJiang Pi

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Methods Mentioned

BETA
transmission electron microscopy
MDA

Software Mentioned

Digital Micrograph
Soft Imaging Viewer

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