Selenium provides protection to the liver but not the reproductive organs in an atrazine-model of experimental toxicity

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
A C AdesiyanE O Farombi

Abstract

The present study evaluated the possible protective effects of selenium against atrazine-induced toxicity in the liver and reproductive system of rats. Atrazine administered to rats orally at a dose of 120 mg/kg caused an inhibition in the activity of glutathione-S-transferase and an increase in malondialdehyde formation in the liver, testis and epididymis. Superoxide dismutase decreased in the liver and testis but was increased in the epididymis. Furthermore, hepatic glutathione and lactate dehydrogenase activity increased while epididymal catalase, ascorbate content, hepatic aspartate aminotransferase and glutathione peroxidase activities in all the tissues decreased in the atrazine-treated animals. Hepatic, testicular and epididymal alanine aminotransferase activities were not affected by atrazine (p>0.05). Decreased epididymal and testicular sperm number, sperm motility, daily sperm production and increased number of dead and abnormal sperm were observed in atrazine-treated rats. Treatment of rats orally with selenium at a dose of 0.25 mg/kg did not prevent atrazine-induced changes in sperm characteristics and had no protective effects against atrazine-induced biochemical alterations in the testis and epididymis except test...Continue Reading

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Citations

Jul 11, 2012·Toxicology International·S O AbarikwuD Osobu
Apr 7, 2012·Journal of Toxicology and Environmental Health. Part a·Taewon LeeVarsha G Desai
Jul 17, 2012·Environmental Toxicology and Pharmacology·Kristina Pogrmic-MajkicRadmila Kovacevic
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May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rabie L Abdel AzizAbdel-Tawab A Y Khalil
Jan 8, 2022·Environmental Science and Pollution Research International·Yasmine H AhmedZainab Sabry Othman Ahmed

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