Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

Free Radical Biology & Medicine
Nikolay SolovyevMargaret P Rayman

Abstract

The essential trace element, selenium (Se), is crucial to the brain but it may be potentially neurotoxic, depending on dosage and speciation; Se has been discussed for decades in relation to Alzheimer's disease (AD). Selenoprotein P (SELENOP) is a secreted heparin-binding glycoprotein which serves as the main Se transport protein in mammals. In vivo studies showed that this protein might have additional functions such as a contribution to redox regulation. The current review focuses on recent research on the possible role of SELENOP in AD pathology, based on model and human studies. The review also briefly summarizes results of epidemiological studies on Se supplementation in relation to brain diseases, including PREADViSE, EVA, and AIBL. Although mainly positive effects of Se are assessed in this review, possible detrimental effects of Se supplementation or exposure, including potential neurotoxicity, are also mentioned. In relation to AD, various roles of SELENOP are discussed, i.e. as the means of Se delivery to neurons, as an antioxidant, in cytoskeleton assembly, in interaction with redox-active metals (copper, iron, and mercury) and with misfolded proteins (amyloid-beta and hyperphosphorylated tau-protein).

Citations

Oct 4, 2018·The Journal of Nutrition·Xin Gen Lei, Raymond F Burk
Sep 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhen AnRenjun Pei
Feb 7, 2020·Molecular Neurobiology·Geir BjørklundSalvatore Chirumbolo
Jul 4, 2019·Current Pharmaceutical Design·Harry RobberechtNina Hermans
Oct 12, 2018·Nutrients·Diana Constantinescu-AruxandeiFlorin Oancea
Jun 27, 2019·Biological Trace Element Research·Huimin Ying, Yan Zhang
Apr 11, 2019·Molecular Neurobiology·Geir BjørklundSalvatore Chirumbolo
Jun 30, 2019·Hormones : International Journal of Endocrinology and Metabolism·Nikolay Solovyev
Jan 29, 2019·Metallomics : Integrated Biometal Science·Natalia V DolgovaIngrid J Pickering
Mar 17, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJan Aaseth
Dec 29, 2020·Frontiers in Molecular Neuroscience·Supriya BehlMukesh K Pandey
Jan 15, 2021·The Science of the Total Environment·Mohammad NaderiRaymond W M Kwong
Feb 12, 2021·Metallomics : Integrated Biometal Science·Evgenii DrobyshevTanja Schwerdtle
Jul 28, 2018·Free Radical Biology & Medicine·Nicholas Vc Ralston
Feb 23, 2021·Frontiers in Neuroscience·Nikolay SolovyevBernhard Michalke
May 4, 2021·Frontiers in Neuroscience·Daniel J TorresMarla J Berry
Jun 15, 2021·Advanced Healthcare Materials·Cláudio FerroHélder A Santos
Dec 15, 2020·Journal of Agricultural and Food Chemistry·Xing ZhangTao Hou
Aug 26, 2021·Life Science Alliance·Xi LiangYinghe Xu
Sep 4, 2019·ACS Applied Materials & Interfaces·Wenshu CongChunying Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

© 2022 Meta ULC. All rights reserved