Selenium Status in Diet Affects Acetaminophen-Induced Hepatotoxicity via Interruption of Redox Environment.

Antioxidants & Redox Signaling
Jing LiJun Lu

Abstract

Aims: Drug-induced liver injury, especially acetaminophen (APAP)-induced liver injury, is a leading cause of liver failure worldwide. Mouse models were used to evaluate the effect of microelement selenium levels on the cellular redox environment and consequent hepatotoxicity of APAP. Results: APAP treatment affected mouse liver selenoprotein thioredoxin reductase (TrxR) activity and glutathione (GSH) level in a dose- and time-dependent manner. Decrease of mouse liver TrxR activity and glutathione level was an early event, and occurred concurrently with liver damage. The decreases in the GSH/glutathione disulfide form (GSSG) ratio and TrxR activity, and the increase of protein S-glutathionylation were correlated with the APAP-induced hepatotoxicity. Moreover, in APAP-treated mice both mild deprivation and excess supplementation with selenium increased the severity of liver injury compared with those observed in mice with normal dietary selenium levels. An increase in the oxidation state of the TrxR-mediated system, including cytosolic thioredoxin1 (Trx1) and peroxiredoxin1/2 (Prx1/2), and mitochondrial Trx2 and Prx3, was found in the livers from mice reared on selenium-deficient and excess selenium-supplemented diets upon APAP t...Continue Reading

References

May 25, 1989·The New England Journal of Medicine
Aug 1, 1988·Toxicology and Applied Pharmacology·R C SchnellS W Weir
Feb 9, 1973·Science·J T RotruckW G Hoekstra
Dec 21, 1994·JAMA : the Journal of the American Medical Association·D C Whitcomb, G D Block
Nov 1, 1996·Seminars in Liver Disease·M R Losser, D Payen
May 19, 1997·Biochemical and Biophysical Research Communications·K E HillR F Burk
May 15, 2002·Addiction Biology·Stephen M Riordan, Roger Williams
Jul 24, 2002·Nutrition in Clinical Care : an Official Publication of Tufts University·Raymond F Burk
Jan 9, 2003·Trends in Biochemical Sciences·Zachary A WoodLeslie B Poole
Mar 22, 2003·The Journal of Biological Chemistry·Ellen R TaylorMichael P Murphy
May 31, 2003·Science·Gregory V KryukovVadim N Gladyshev
Jun 24, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Aug 2, 2003·The New England Journal of Medicine·William M Lee
Nov 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Laura P JamesJack A Hinson
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anne M LarsonUNKNOWN Acute Liver Failure Study Group
Feb 17, 2006·The New England Journal of Medicine·Victor J Navarro, John R Senior
May 19, 2007·Antioxidants & Redox Signaling·Laura Vanda PappKum Kum Khanna
Aug 29, 2007·Clinics in Liver Disease·Anne M Larson
Feb 19, 2008·Free Radical Biology & Medicine·Raymond F BurkLori M Austin
Sep 2, 2008·The Journal of Biological Chemistry·Jun Lu, Arne Holmgren
Apr 9, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jun LuArne Holmgren
Oct 13, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chieko SaitoHartmut Jaeschke
Nov 13, 2009·Antioxidants & Redox Signaling·Laura V PappKum Kum Khanna
Sep 28, 2010·Archives of Toxicology·Jela BrozmanováMiroslav Chovanec
Apr 26, 2012·Antioxidants & Redox Signaling·Jun Lu, Arne Holmgren
Feb 21, 2013·Nutrition·Marek Kieliszek, Stanisław Błażejak
Jun 8, 2013·Free Radical Biology & Medicine·Sonya V IversonEdward E Schmidt
Aug 1, 2013·Free Radical Biology & Medicine·Jun Lu, Arne Holmgren
Mar 22, 2014·Trends in Biochemical Sciences·John D Hayes, Albena T Dinkova-Kostova
Mar 26, 2014·Chemical Research in Toxicology·Yi-Hua JanJeffrey D Laskin
Dec 3, 2014·Biochimica Et Biophysica Acta·Aristi P Fernandes, Valentina Gandin
Nov 16, 2016·Clinics in Liver Disease·Amina Ibrahim ShehuRaman Venkataramanan
Dec 14, 2017·Nature Communications·Lucía Barbier-TorresMaría Luz Martínez-Chantar
Feb 8, 2018·Metallomics : Integrated Biometal Science·Yanfang OuyangJun Lu
Mar 20, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Xianxun ShiAiling Fu

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
immunoprecipitation assay

Software Mentioned

ImageJ
GraphPad Prism
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Pharmacology
Anna MolesJose C Fernandez-Checa
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Hong-Min NiWen-Xing Ding
Toxicological Sciences : an Official Journal of the Society of Toxicology
Guoli DaiYu-Jui Yvonne Wan
© 2022 Meta ULC. All rights reserved